about
Intramolecular regulation of protein tyrosine phosphatase SH-PTP1: a new function for Src homology 2 domainsThe microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis.The liver-specific microRNA miR-122 controls systemic iron homeostasis in miceSpecific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signalsReport on EU-USA workshop: how systems biology can advance cancer research (27 October 2008)Computational processing and error reduction strategies for standardized quantitative data in biological networks.Quantitative data generation for systems biology: the impact of randomisation, calibrators and normalisers.TTCA: an R package for the identification of differentially expressed genes in time course microarray dataSelf assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor.Dynamics of receptor and protein transducer homodimerisation.Model-based extension of high-throughput to high-content data.Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisionsCombining theoretical analysis and experimental data generation reveals IRF9 as a crucial factor for accelerating interferon α-induced early antiviral signalling.Knowledge-based matrix factorization temporally resolves the cellular responses to IL-6 stimulation.In silico labeling reveals the time-dependent label half-life and transit-time in dynamical systems.Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells.Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood.Lessons learned from quantitative dynamical modeling in systems biology.Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range.Leukemogenic Ptpn11 allele causes defective erythropoiesis in mice.Disentangling the Complexity of HGF Signaling by Combining Qualitative and Quantitative Modeling.Erythropoietin improves the accumulation and therapeutic effects of carboplatin by enhancing tumor vascularization and perfusionCytokinesis failure in RhoA-deficient mouse erythroblasts involves actomyosin and midbody dysregulation and triggers p53 activationIdentification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors.Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells.An integrative model links multiple inputs and signaling pathways to the onset of DNA synthesis in hepatocytes.Systems biology of JAK/STAT signalling.Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5.Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling.Protein abundance of AKT and ERK pathway components governs cell type-specific regulation of proliferation.Predictive mathematical models of cancer signalling pathways.Receptor dynamics in signaling.Unraveling liver complexity from molecular to organ level: challenges and perspectives.Context-specific flow through the MEK/ERK module produces cell- and ligand-specific patterns of ERK single and double phosphorylation.Identification of isoform-specific dynamics in phosphorylation-dependent STAT5 dimerization by quantitative mass spectrometry and mathematical modeling.IL-1β-induced and p38MAPK-dependent activation of the mitogen-activated protein kinase-activated protein kinase 2 (MK2) in hepatocytes: Signal transduction with robust and concentration-independent signal amplification.Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration.Dynamics and feedback loops in the transforming growth factor β signaling pathway.Targeted near-infrared imaging of the erythropoietin receptor in human lung cancer xenografts.Centrosomal targeting of tyrosine kinase activity does not enhance oncogenicity in chronic myeloproliferative disorders.
P50
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P50
description
hulumtuese
@sq
onderzoeker
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researcher
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ricercatrice
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հետազոտող
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name
Ursula Klingmüller
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Ursula Klingmüller
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Ursula Klingmüller
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Ursula Klingmüller
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Ursula Klingmüller
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type
label
Ursula Klingmüller
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Ursula Klingmüller
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Ursula Klingmüller
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Ursula Klingmüller
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Ursula Klingmüller
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altLabel
Klingmüller U
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prefLabel
Ursula Klingmüller
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Ursula Klingmüller
@de
Ursula Klingmüller
@en
Ursula Klingmüller
@es
Ursula Klingmüller
@sl
P227
P1053
G-8477-2013
P21
P214
486146216549409090789
P227
1098573455
P2456
P31
P3829
P496
0000-0001-9845-3099
P569
1964-01-01T00:00:00Z
P735
P7859
viaf-486146216549409090789