Modeling of G-protein-coupled receptors: application to dopamine, adrenaline, serotonin, acetylcholine, and mammalian opsin receptors.
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The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptorsGeometry of interplanar residue contacts in protein structuresDesign, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptorExploration of the ligand binding site of the human 5-HT(4) receptor by site-directed mutagenesis and molecular modelingTyr115 is the key residue for determining agonist selectivity in the V1a vasopressin receptorProtein-assisted pericyclic reactions: an alternate hypothesis for the action of quantal receptors.Automated method for modeling seven-helix transmembrane receptors from experimental data.Residues in the first extracellular loop of a G protein-coupled receptor play a role in signal transduction.Conserved aromatic residues in the transmembrane region VI of the V1a vasopressin receptor differentiate agonist vs. antagonist ligand binding.Modelling the structures of G protein-coupled receptors aided by three-dimensional validation.Functional architecture of vasopressin/oxytocin receptors.Constitutive activation of the delta opioid receptor by mutations in transmembrane domains III and VII.Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptorBufotenine: toward an understanding of possible psychoactive mechanisms.Molecular mechanisms of bitopic ligand engagement with the M1 muscarinic acetylcholine receptorA proposed structure for transmembrane segment 7 of G protein-coupled receptors incorporating an asn-Pro/Asp-Pro motif.Peptide hormone binding to G-protein-coupled receptors: structural characterization via NMR techniques.Molecular Architecture of G Protein-Coupled Receptors.Conformational changes of G protein-coupled receptors during their activation by agonist binding.Tyr-129 is important to the peptide ligand affinity and selectivity of human endothelin type A receptor.Multicomponent Synthesis and Biological Evaluation of a Piperazine-Based Dopamine Receptor Ligand Library.Constitutively active mutants of the alpha 1B-adrenergic receptor: role of highly conserved polar amino acids in receptor activation.The second extracellular loop of alpha2A-adrenoceptors contributes to the binding of yohimbine analoguesRole of the serotonergic system in alcohol dependence: from animal models to clinics.Molecular recognition of opioid receptor ligands.Role of 5-hydroxytryptamine 1B (5-HT1B) receptors in the regulation of ethanol intake in rodents.Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor.Molecular recognition of organic ammonium ions in solution using synthetic receptorsCocaine-induced adaptations in metabotropic inhibitory signaling in the mesocorticolimbic system.Inflammatory mechanisms in the pathogenesis of pulmonary arterial hypertension.A common molecular motif characterizes extracellular allosteric enhancers of GPCR aminergic receptors and suggests enhancer mechanism of action.Two amino acids, located in transmembrane domains VI and VII, determine the selectivity of the peptide agonist SMS 201-995 for the SSTR2 somatostatin receptorProposed ligand binding site of the transmembrane receptor for neurotensin(8-13).Direct identification of a distinct site of interaction between the carboxyl-terminal residue of cholecystokinin and the type A cholecystokinin receptor using photoaffinity labeling.Roles of threonine 192 and asparagine 382 in agonist and antagonist interactions with M1 muscarinic receptors.Strategies for positioning fluorescent probes and crosslinkers on formyl peptide ligands.Two aromatic residues regulate the response of the human oxytocin receptor to the partial agonist arginine vasopressin.Cloning and characterisation of the rabbit 5-HT1D alpha and 5-HT1D beta receptors.Mutational analysis of the relative orientation of transmembrane helices I and VII in G protein-coupled receptors.How receptor mutagenesis may confirm or confuse receptor classification.
P2860
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P2860
Modeling of G-protein-coupled receptors: application to dopamine, adrenaline, serotonin, acetylcholine, and mammalian opsin receptors.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Modeling of G-protein-coupled ...... and mammalian opsin receptors.
@en
type
label
Modeling of G-protein-coupled ...... and mammalian opsin receptors.
@en
prefLabel
Modeling of G-protein-coupled ...... and mammalian opsin receptors.
@en
P2093
P356
P1476
Modeling of G-protein-coupled ...... and mammalian opsin receptors.
@en
P2093
Bruinvels A
Trumpp-Kallmeyer S
P304
P356
10.1021/JM00097A002
P407
P577
1992-09-01T00:00:00Z