Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic beta-cell line INS-1.
about
Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteinsCarboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosisChronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cellsTranscriptional regulation of the murine acetyl-CoA synthetase 1 gene through multiple clustered binding sites for sterol regulatory element-binding proteins and a single neighboring site for Sp1Adenovirus-mediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: effects on cell metabolism and insulin secretionFat depot origin affects fatty acid handling in cultured rat and human preadipocytes.Co-regulation of tissue-specific alternative human carnitine palmitoyltransferase Ibeta gene promoters by fatty acid enzyme substrate.Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase.The malonyl-CoA-long-chain acyl-CoA axis in the maintenance of mammalian cell function.Lipid infusion lowers sympathetic nervous activity and leads to increased beta-cell responsiveness to glucose.Long-chain acyl coenzyme A synthetase 1 overexpression in primary cultured Schwann cells prevents long chain fatty acid-induced oxidative stress and mitochondrial dysfunction.Fatty acid regulation of gene transcription.Evidence that multiple defects in lipid regulation occur before hyperglycemia during the prodrome of type-2 diabetes.Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue.Diet supplementation with green tea extract epigallocatechin gallate prevents progression to glucose intolerance in db/db mice.Metabolic cycling in control of glucose-stimulated insulin secretionElevated insulin secretion from liver X receptor-activated pancreatic beta-cells involves increased de novo lipid synthesis and triacylglyceride turnoverFatty acid-induced beta cell hypersensitivity to glucose. Increased phosphofructokinase activity and lowered glucose-6-phosphate content.Nutrition-/diet-induced changes in gene expression in pancreatic β-cells.ICER-1gamma overexpression drives palmitate-mediated connexin36 down-regulation in insulin-secreting cells.Stevioside counteracts the alpha-cell hypersecretion caused by long-term palmitate exposure.Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells.Palmitic acid-rich diet suppresses glucose-stimulated insulin secretion (GSIS) and induces endoplasmic reticulum (ER) stress in pancreatic islets in mice.Differential action of fatty acids against streptozotocin induced in vitro cytotoxicity in islets.Glibenclamide inhibits islet carnitine palmitoyltransferase 1 activity, leading to PKC-dependent insulin exocytosis.Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis.Chronic high glucose lowers pyruvate dehydrogenase activity in islets through enhanced production of long chain acyl-CoA: prevention of impaired glucose oxidation by enhanced pyruvate recycling through the malate-pyruvate shuttle.Non-esterified fatty acids are deleterious for human pancreatic islet function at physiological glucose concentration.Regulation of acetyl CoA carboxylase and carnitine palmitoyl transferase-1 in rat adipocytes.Effects of Dietary Fatty Acids in Pancreatic Beta Cell Metabolism, Implications in Homeostasis.
P2860
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P2860
Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic beta-cell line INS-1.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Fatty acids rapidly induce the ...... ncreatic beta-cell line INS-1.
@en
type
label
Fatty acids rapidly induce the ...... ncreatic beta-cell line INS-1.
@en
prefLabel
Fatty acids rapidly induce the ...... ncreatic beta-cell line INS-1.
@en
P2093
P2860
P356
P1476
Fatty acids rapidly induce the ...... ancreatic beta-cell line INS-1
@en
P2093
F Assimacopoulos-Jeannet
J D McGarry
S Thumelin
P2860
P304
P356
10.1074/JBC.272.3.1659
P407
P577
1997-01-01T00:00:00Z