Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo.
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GARP: a surface molecule of regulatory T cells that is involved in the regulatory function and TGF-β releasingLysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor β1 (TGF-β1) Production in Human Regulatory T Cells.Limited Impact of Imatinib in a Murine Model of Sclerodermatous Chronic Graft-versus-Host DiseaseThe role of platelet and endothelial GARP in thrombosis and hemostasis.Combining FoxP3 and Helios with GARP/LAP markers can identify expanded Treg subsets in cancer patients.The frequency and skewed T-cell receptor beta-chain variable patterns of peripheral CD4(+)CD25(+) regulatory T-cells are associated with hepatitis B e antigen seroconversion of chronic hepatitis B patients during antiviral treatment.Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells.Matters of context guide future research in TGFβ superfamily signaling.Azacytidine prevents experimental xenogeneic graft-versus-host disease without abrogating graft-versus-leukemia effects.Novel approaches for preventing acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.Immunomodulatory antibodies for the treatment of lymphoma: Report on the CALYM WorkshopRegulation of the Bioavailability of TGF-β and TGF-β-Related Proteins.Garp as a therapeutic target for modulation of T regulatory cell function.Targeting immunosuppression by Tregs with monoclonal antibodies against GARPThe GARP/Latent TGF-β1 complex on Treg cells modulates the induction of peripherally derived Treg cells during oral tolerance.Cutting Edge: Active TGF-β1 Released from GARP/TGF-β1 Complexes on the Surface of Stimulated Human B Lymphocytes Increases Class-Switch Recombination and Production of IgA.Platelets subvert T cell immunity against cancer via GARP-TGFβ axis.Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8.Regulatory T cells control toxicity in a humanized model of IL-2 therapy.Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells.Glycoprotein A repetitions predominant (GARP) positively regulates transforming growth factor (TGF) β3 and is essential for mouse palatogenesis.Role of GARP in the activation of latent TGF-β1.IL-6 Inhibits Upregulation of Membrane-Bound TGF-β 1 on CD4+ T Cells and Blocking IL-6 Enhances Oral Tolerance.Immunoregulatory functions and the therapeutic implications of GARP-TGF-β in inflammation and cancer.Foxp3+ T Regulatory Cells: Still Many Unanswered Questions-A Perspective After 20 Years of Study.
P2860
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P2860
Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo.
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name
Monoclonal antibodies against ...... an regulatory T cells in vivo.
@en
type
label
Monoclonal antibodies against ...... an regulatory T cells in vivo.
@en
prefLabel
Monoclonal antibodies against ...... an regulatory T cells in vivo.
@en
P2093
P2860
P50
P1476
Monoclonal antibodies against ...... man regulatory T cells in vivo
@en
P2093
Bas van der Woning
Caroline Huygens
Didier Colau
Frédéric Baron
Gitte De Boeck
Hans De Haard
Joan Somja
Julia Cuende
Laure Dumoutier
Michael Saunders
P2860
P304
P356
10.1126/SCITRANSLMED.AAA1983
P407
P577
2015-04-01T00:00:00Z