Arginine topology controls escape of minimally cationic proteins from early endosomes to the cytoplasm. - Test2 - elhamkhani - TriplyDB

Arginine topology controls escape of minimally cationic proteins from early endosomes to the cytoplasm.

Arginine topology controls escape of minimally cationic proteins from early endosomes to the cytoplasm.

http://www.wikidata.org/entity/Q41500169

about

Getting in shape: controlling peptide bioactivity and bioavailability using conformational constraints Attachment of cell-binding ligands to arginine-rich cell-penetrating peptides enables cytosolic translocation of complexed siRNA.A bicyclic peptide scaffold promotes phosphotyrosine mimicry and cellular uptake Improved assays for determining the cytosolic access of peptides, proteins, and their mimetics.Artificial disulfide-rich peptide scaffolds with precisely defined disulfide patterns and a minimized number of isomers.Early endosomal escape of a cyclic cell-penetrating peptide allows effective cytosolic cargo delivery.Dual peptide conjugation strategy for improved cellular uptake and mitochondria targeting Monitoring the cytosolic entry of cell-penetrating peptides using a pH-sensitive fluorophore Liver-targeted antiviral peptide nanocomplexes as potential anti-HCV therapeutics Substrate-initiated synthesis of cell-penetrating poly(disulfide)s A general strategy for generating intact, full-length IgG antibodies that penetrate into the cytosol of living cells.Fluorescence correlation spectroscopy reveals highly efficient cytosolic delivery of certain penta-arg proteins and stapled peptides Mechanism Matters: A Taxonomy of Cell Penetrating Peptides.A Miniature Protein Stabilized by a Cation-π Interaction Network Fifteen years of cell-penetrating, guanidinium-rich molecular transporters: basic science, research tools, and clinical applications Improving the endosomal escape of cell-penetrating peptides and their cargos: strategies and challenges.Layer-by-layer nanoparticles for systemic codelivery of an anticancer drug and siRNA for potential triple-negative breast cancer treatment Getting across the cell membrane: an overview for small molecules, peptides, and proteins.Cationic cell-penetrating peptides as vehicles for siRNA delivery.Global analysis of protein folding using massively parallel design, synthesis, and testing.Inhibiting epidermal growth factor receptor at a distance.Nanoescapology: progress toward understanding the endosomal escape of polymeric nanoparticles.Supramolecular functional assemblies: dynamic membrane transporters and peptide nanotubular composites.Development of a Cell-penetrating Peptide that Exhibits Responsive Changes in its Secondary Structure in the Cellular Environment.Influence of macrocyclization on allosteric, juxtamembrane-derived, stapled peptide inhibitors of the epidermal growth factor receptor (EGFR).Resurfaced cell-penetrating nanobodies: A potentially general scaffold for intracellularly targeted protein discovery.Efficient delivery of cyclic peptides into mammalian cells with short sequence motifs.Layer-by-layer nanoparticles as an efficient siRNA delivery vehicle for SPARC silencing.Poly-arginine and arginine-rich peptides are neuroprotective in stroke models.Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets.Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8.Unlocking Endosomal Entrapment with Supercharged Arginine-Rich Peptides.Small Scaffolds, Big Potential: Developing Miniature Proteins as Therapeutic Agents.A Cyclized Helix-Loop-Helix Peptide as a Molecular Scaffold for the Design of Inhibitors of Intracellular Protein-Protein Interactions by Epitope and Arginine Grafting.Peptide/Cas9 nanostructures for ribonucleoprotein cell membrane transport and gene edition.Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell Type Specific Gene Editing.Achieving enhanced cell penetration of short conformationally constrained peptides through amphiphilicity tuning.Cell-penetrating poly(disulfide)s: the dependence of activity, depolymerization kinetics and intracellular localization on their length Fluorescence Correlation Spectroscopy Reveals Efficient Cytosolic Delivery of Protein Cargo by Cell-Permeant Miniature Proteins Cell Penetration Profiling Using the Chloroalkane Penetration Assay

P2860

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P2860

Arginine topology controls escape of minimally cationic proteins from early endosomes to the cytoplasm.

http://www.wikidata.org/entity/Q41500169

description

2012 nî lūn-bûn

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2012年论文

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name

Arginine topology controls esc ...... ly endosomes to the cytoplasm.

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Arginine topology controls esc ...... ly endosomes to the cytoplasm.

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Arginine topology controls esc ...... ly endosomes to the cytoplasm.

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J.CHEMBIOL.2012.05.022

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Chemistry and Biology

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Arginine topology controls esc ...... ly endosomes to the cytoplasm.

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Alanna Schepartz

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Betsy A Smith

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Daniel M Balkin

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Jacob S Appelbaum

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Jonathan R LaRochelle

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Justin M Holub

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P2860

Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes.

A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo

Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles

CellProfiler: image analysis software for identifying and quantifying cell phenotypes

Rab7 associates with early endosomes to mediate sorting and transport of Semliki forest virus to late endosomes

Endosome maturation

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Genome editing with engineered zinc finger nucleases

Mechanisms of endocytosis

Rab conversion as a mechanism of progression from early to late endosomes

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10.1016/J.CHEMBIOL.2012.05.022

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7

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19

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22840770

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3488872

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