Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
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Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin LigationSAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S E2s to ubiquitylate β-TrCP1 via K11-linkage for degradationSaturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21WD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity.Building a Regulatory Network with Short Linear Sequence Motifs: Lessons from the Degrons of the Anaphase-Promoting Complex.Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism.Dynamic ubiquitin signaling in cell cycle regulation.Crosstalk and Interplay between the Ubiquitin-Proteasome System and Autophagy.The mitotic checkpoint complex (MCC): looking back and forth after 15 years.Synergistic inhibition of the APC/C by the removal of APC15 in HCT116 cells lacking UBE2C.A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control.Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination.Molecular Mechanisms of Spindle Assembly Checkpoint Activation and Silencing.Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C).A muscle-specific MuRF1-E2 network requires stabilization of MuRF1-E2 complexes by telethonin, a newly identified substrate.Site-specific inhibition of the small ubiquitin-like modifier (SUMO)-conjugating enzyme Ubc9 selectively impairs SUMO chain formation.Specific targeting of the deubiquitinase and E3 ligase families with engineered ubiquitin variants.Ube2s stabilizes β-Catenin through K11-linked polyubiquitination to promote mesendoderm specification and colorectal cancer development.SUMO targets the APC/C to regulate transition from metaphase to anaphase.Sumoylation promotes optimal APC/C Activation and Timely Anaphase.
P2860
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P2860
Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年学术文章
@wuu
2016年学术文章
@zh-cn
2016年学术文章
@zh-hans
2016年学术文章
@zh-my
2016年学术文章
@zh-sg
2016年學術文章
@yue
2016年學術文章
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2016年學術文章
@zh-hant
name
Dual RING E3 Architectures Reg ...... tin Chain Elongation by APC/C.
@en
type
label
Dual RING E3 Architectures Reg ...... tin Chain Elongation by APC/C.
@en
prefLabel
Dual RING E3 Architectures Reg ...... tin Chain Elongation by APC/C.
@en
P2093
P2860
P50
P1433
P1476
Dual RING E3 Architectures Reg ...... itin Chain Elongation by APC/C
@en
P2093
Brian Kuhlman
Christy R R Grace
Darcie J Miller
David Yanishevski
Edmond R Watson
Holger Stark
Iain F Davidson
Jan-Michael Peters
Kuen-Phon Wu
Marc A Jarvis
P2860
P304
P356
10.1016/J.CELL.2016.05.037
P407
P50
P577
2016-06-01T00:00:00Z