Induction of resistance to alkylating agents in E. coli: the ada+ gene product serves both as a regulatory protein and as an enzyme for repair of mutagenic damage.
about
The modified human DNA repair enzyme O(6)-methylguanine-DNA methyltransferase is a negative regulator of estrogen receptor-mediated transcription upon alkylation DNA damageDefective processing of methylated single-stranded DNA by E. coli AlkB mutantsMethyl phosphotriesters in alkylated DNA are repaired by the Ada regulatory protein of E. coliTranscriptional regulation of human DNA repair genes following genotoxic stress: trigger mechanisms, inducible responses and genotoxic adaptationCrystal structure of a suicidal DNA repair protein: the Ada O6-methylguanine-DNA methyltransferase from E. coliIdentification of methylated proteins in the yeast small ribosomal subunit: a role for SPOUT methyltransferases in protein arginine methylation.Regulatory responses of the adaptive response to alkylation damage: a simple regulon with complex regulatory featuresIncreased spontaneous mutation and alkylation sensitivity of Escherichia coli strains lacking the ogt O6-methylguanine DNA repair methyltransferaseMolecular characterization of an adaptive response to alkylating agents in the opportunistic pathogen Aspergillus fumigatusThe solution structure of the methylated form of the N-terminal 16-kDa domain of Escherichia coli Ada protein.A second DNA methyltransferase repair enzyme in Escherichia coli.Complementation of sensitivity to alkylating agents in Escherichia coli and Chinese hamster ovary cells by expression of a cloned bacterial DNA repair gene.Alteration of lysine 178 in the hinge region of the Escherichia coli ada protein interferes with activation of ada, but not alkA, transcription.The Ada protein acts as both a positive and a negative modulator of Escherichia coli's response to methylating agents.Bacillus subtilis ada operon encodes two DNA alkyltransferases.Alternative pathways for the in vivo repair of O6-alkylguanine and O4-alkylthymine in Escherichia coli: the adaptive response and nucleotide excision repair.New method for gene disruption in Salmonella typhimurium: construction and characterization of an ada-deletion derivative of Salmonella typhimurium TA1535.Cloning and characterization of the Salmonella typhimurium ada gene, which encodes O6-methylguanine-DNA methyltransferaseSeparation of the SOS-dependent and SOS-independent components of alkylating-agent mutagenesisCharacterization of the major DNA repair methyltransferase activity in unadapted Escherichia coli and identification of a similar activity in Salmonella typhimurium.Inhibition of the SOS response of Escherichia coli by the Ada protein.Construction of an Escherichia coli K-12 ada deletion by gene replacement in a recD strain reveals a second methyltransferase that repairs alkylated DNAAlteration of the carboxyl-terminal domain of Ada protein influences its inducibility, specificity, and strength as a transcriptional activatorMultiple species of Bacillus subtilis DNA alkyltransferase involved in the adaptive response to simple alkylating agentsDNA Polymerases ImuC and DinB Are Involved in DNA Alkylation Damage Tolerance in Pseudomonas aeruginosa and Pseudomonas putidaInduction and autoregulation of ada, a positively acting element regulating the response of Escherichia coli K-12 to methylating agents.Induction of transversion mutations in Escherichia coli by N-methyl-N'-nitro-N-nitrosoguanidine is SOS dependentCloning of the E. coli O6-methylguanine and methylphosphotriester methyltransferase gene using a functional DNA repair assay.Expression of the yeast PHR1 gene is induced by DNA-damaging agentsDNA-mediated transfer and expression of a human DNA repair gene that demethylates O6-methylguanine.Suppression of human DNA alkylation-repair defects by Escherichia coli DNA-repair genes.Reduction of the toxicity and mutagenicity of alkylating agents in mammalian cells harboring the Escherichia coli alkyltransferase gene.Regulatory mechanisms for induction of synthesis of repair enzymes in response to alkylating agents: ada protein acts as a transcriptional regulatoruvrA and recA mutations inhibit a site-specific transition produced by a single O6-methylguanine in gene G of bacteriophage phi X174.A region of the Ada DNA-repair protein required for the activation of ada transcription is not necessary for activation of alkAActive site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesisDifferences in mutagenic and recombinational DNA repair in enterobacteria.My journey to DNA repair.DNA-binding mechanism of the Escherichia coli Ada O(6)-alkylguanine-DNA alkyltransferase.The 1987 Walter Hubert lecture. Regulation and deficiencies in DNA repair.
P2860
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P2860
Induction of resistance to alkylating agents in E. coli: the ada+ gene product serves both as a regulatory protein and as an enzyme for repair of mutagenic damage.
description
1984 nî lūn-bûn
@nan
1984年の論文
@ja
1984年論文
@yue
1984年論文
@zh-hant
1984年論文
@zh-hk
1984年論文
@zh-mo
1984年論文
@zh-tw
1984年论文
@wuu
1984年论文
@zh
1984年论文
@zh-cn
name
Induction of resistance to alk ...... or repair of mutagenic damage.
@en
type
label
Induction of resistance to alk ...... or repair of mutagenic damage.
@en
prefLabel
Induction of resistance to alk ...... or repair of mutagenic damage.
@en
P2093
P2860
P1433
P1476
Induction of resistance to alk ...... for repair of mutagenic damage
@en
P2093
P2860
P304
P356
10.1002/J.1460-2075.1984.TB02105.X
P407
P577
1984-09-01T00:00:00Z