about
ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4+ T cellsHomozygous loss of ICOS is associated with adult-onset common variable immunodeficiencyRoquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNAOntogenic, Phenotypic, and Functional Characterization of XCR1(+) Dendritic Cells Leads to a Consistent Classification of Intestinal Dendritic Cells Based on the Expression of XCR1 and SIRPαICOS controls the pool size of effector-memory and regulatory T cells.ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2.MicroRNA-146a regulates ICOS-ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres.Emerging paradigms of T-cell co-stimulation.IFNAR1-Signalling Obstructs ICOS-mediated Humoral Immunity during Non-lethal Blood-Stage Plasmodium Infection.Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells.Adequate immune response ensured by binary IL-2 and graded CD25 expression in a murine transfer model.Anti-CD83 promotes IgG1 isotype switch in marginal zone B cells in response to TI-2 antigen.The translocation motif of hepatitis B virus improves protein vaccination.[T and B cell immune reactions in inflamed tissue].ICOS regulates the pool of group 2 innate lymphoid cells under homeostatic and inflammatory conditions in mice.Induction of potent CD8 T cell cytotoxicity by specific targeting of antigen to cross-presenting dendritic cells in vivo via murine or human XCR1.Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10.Inducible costimulator (ICOS) blockade inhibits accumulation of polyfunctional T helper 1/T helper 17 cells and mitigates autoimmune arthritis.Regulation of T follicular helper cells by ICOS.The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses.ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses.Tolerance induction with T cell-dependent protein antigens induces regulatory sialylated IgGs.Lipopolysaccharide stimulation of dendritic cells induces interleukin-10 producing allergen-specific T cells in vitro but fails to prevent allergic airway disease.T-follicular helper cells survive as long-term memory cells.Impact of inducible co-stimulatory molecule (ICOS) on T-cell responses and protection against Mycobacterium tuberculosis infection.Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses.ICOS Costimulation Differentially Affects T Cells in Secondary Lymphoid Organs and Inflamed Tissues.Comprehensive analysis of CD4+ T cells in the decision between tolerance and immunity in vivo reveals a pivotal role for ICOS.Prenatal allergen exposures prevent allergen-induced sensitization and airway inflammation in young mice.Reduced Treg frequency in LFA-1-deficient mice allows enhanced T effector differentiation and pathology in EAE.Cutting edge: Plasmacytoid dendritic cells induce IL-10 production in T cells via the Delta-like-4/Notch axis.Selective expression of the chemokine receptor XCR1 on cross-presenting dendritic cells determines cooperation with CD8+ T cells.BCG priming of dendritic cells enhances T regulatory and Th1 function and suppresses allergen-induced Th2 function in vitro and in vivo.Eminent role of ICOS costimulation for T cells interacting with plasmacytoid dendritic cells.Inducible costimulator-positive T cells are required for allergen-induced local B-cell infiltration and antigen-specific IgE production in lung tissue.ICOS+ Th cells produce distinct cytokines in different mucosal immune responses.[T-cell costimulation. Basic mechanisms and new aspects]LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma CellsT Follicular Helper-Like Cells in Inflamed Non-Lymphoid Tissues.
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description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Andreas Hutloff
@ast
Andreas Hutloff
@en
Andreas Hutloff
@es
type
label
Andreas Hutloff
@ast
Andreas Hutloff
@en
Andreas Hutloff
@es
prefLabel
Andreas Hutloff
@ast
Andreas Hutloff
@en
Andreas Hutloff
@es
P1053
D-1781-2014
P106
P21
P2798
P31
P3829
P496
0000-0002-0572-8151