Cryo-EM structures of tau filaments from Alzheimer's disease.
about
Monomer-dependent secondary nucleation in amyloid formation.An acetylation-phosphorylation switch that regulates tau aggregation propensity and function.Neurodegeneration: Taming tangled tau.Amyloid-β and tau complexity - towards improved biomarkers and targeted therapies.Synthesis of Thiophene-Based Optical Ligands That Selectively Detect Tau Pathology in Alzheimer's Disease.Brainstem tau pathology in Alzheimer's disease is characterized by increase of three repeat tau and independent of amyloid β.Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau.Hydrogen bonds are a primary driving force for de novo protein folding.Comparative binding properties of the tau PET tracers THK5117, THK5351, PBB3, and T807 in postmortem Alzheimer brains.What is the evidence that tau pathology spreads through prion-like propagation?Mechanistic insights into remodeled Tau-derived PHF6 peptide fibrils by Naphthoquinone-Tryptophan hybrids.HspB1 and Hsc70 chaperones engage distinct tau species and have different inhibitory effects on amyloid formation.Galectin-8-mediated selective autophagy protects against seeded tau aggregation.Distinct differences in prion-like seeding and aggregation between tau protein variants provide mechanistic insights into tauopathies.Salt-induced formations of partially folded intermediates and amyloid fibrils suggests a common underlying mechanism.Energetics Underlying Twist Polymorphisms in Amyloid Fibrils.Modeling Prion-Like Processing of Tau Protein in Alzheimer's Disease for Pharmaceutical Development.Formation and properties of amyloid fibrils of prion protein.Revealing Conformational Variants of Solution-Phase Intrinsically Disordered Tau Protein at the Single-Molecule Level.Zn2+ Interrupts R4-R3 Association Leading to Accelerated Aggregation of Tau Protein.Insights into protein misfolding and aggregation enabled by solid-state NMR spectroscopy.The molecular basis of Alzheimer's plaques.Amyloid fibril polymorphism - a challenge for molecular imaging and therapy.Biophysical Aspects of Alzheimer's Disease: Implications for Pharmaceutical Sciences : Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla.Fibril structure of amyloid-β(1-42) by cryo-electron microscopy.Tau burden and the functional connectome in Alzheimer's disease and progressive supranuclear palsy.Structure-based inhibitors of tau aggregation.Distal Amyloid β-Protein Fragments Template Amyloid Assembly.Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp.The diversity and utility of amyloid fibrils formed by short amyloidogenic peptides.Familial Parkinson's point mutation abolishes multiple system atrophy prion replication.Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease.Cryo-electron microscopy makes waves in pharma labs.Tau can switch microtubule network organizations: from random networks to dynamic and stable bundles.Physical basis of amyloid fibril polymorphism.Tau Filaments and the Development of Positron Emission Tomography Tracers.Simultaneous Determination of Protein Structure and Dynamics Using Cryo-Electron Microscopy.Tau Proteolysis in the Pathogenesis of Tauopathies: Neurotoxic Fragments and Novel Biomarkers.Novel monoclonal antibodies targeting the microtubule-binding domain of human tau.Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
P2860
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P2860
Cryo-EM structures of tau filaments from Alzheimer's disease.
description
2017 nî lūn-bûn
@nan
2017年の論文
@ja
2017年論文
@yue
2017年論文
@zh-hant
2017年論文
@zh-hk
2017年論文
@zh-mo
2017年論文
@zh-tw
2017年论文
@wuu
2017年论文
@zh
2017年论文
@zh-cn
name
Cryo-EM structures of tau filaments from Alzheimer's disease.
@en
type
label
Cryo-EM structures of tau filaments from Alzheimer's disease.
@en
prefLabel
Cryo-EM structures of tau filaments from Alzheimer's disease.
@en
P2093
P2860
P356
P1433
P1476
Cryo-EM structures of tau filaments from Alzheimer's disease
@en
P2093
Alexey G Murzin
Anthony W P Fitzpatrick
Bernardino Ghetti
Garib Murshudov
Holly J Garringer
Michel Goedert
R Anthony Crowther
P2860
P2888
P304
P356
10.1038/NATURE23002
P407
P577
2017-07-05T00:00:00Z
P6179
1090348371