Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity.
about
Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathwayA phase I and pharmacokinetic study of intraperitoneal topotecanThree inhibitors of type 1 human immunodeficiency virus long terminal repeat-directed gene expression and virus replicationDNA duplexes containing 3'-deoxynucleotides as substrates for DNA topoisomerase I cleavage and ligation.Practical synthesis of (20S)-10-(3-aminopropyloxy)-7-ethylcamptothecin, a water-soluble analogue of camptothecin.Poly(amido amine) dendrimers as absorption enhancers for oral delivery of camptothecin.A phase I trial of topotecan and gemcitabine administered weekly for 3 consecutive weeks to patients with advanced tumors.Evaluation of two models for human topoisomerase I interaction with dsDNA and camptothecin derivativesSynergistic targeting of cell membrane, cytoplasm, and nucleus of cancer cells using rod-shaped nanoparticlesMolecular and cytotoxic effects of camptothecin, a topoisomerase I inhibitor, on trypanosomes and LeishmaniaQSAR of phytochemicals for the design of better drugs.Camptothecins in clinical development.Review of the use of topotecan in ovarian carcinoma.Toxicity of the topoisomerase I inhibitors.Bioavailability and pharmacokinetics of oral topotecan: a new topoisomerase I inhibitor.Camptothecin and its analogues: a review on their chemotherapeutic potential.A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin.Ex vivo analysis of topotecan: advancing the application of laboratory-based clinical therapeuticsA phase I study with MAG-camptothecin intravenously administered weekly for 3 weeks in a 4-week cycle in adult patients with solid tumoursAssessing the regioselectivity of OleD-catalyzed glycosylation with a diverse set of acceptors.Topotecan in the management of cervical cancer.Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant.Cancer therapies utilizing the camptothecins: a review of the in vivo literatureFTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathwayNovel camptothecin derivatives as topoisomerase I inhibitors.Diversity through semisynthesis: the chemistry and biological activity of semisynthetic epothilone derivatives.Recent developments and perspectives in palladium-catalyzed cyanation of aryl halides: synthesis of benzonitriles.A pharmacokinetic evaluation of topotecan as a cervical cancer therapy.Cell cycle modulatory and apoptotic effects of plant-derived anticancer drugs in clinical use or development.Differential expression of topoisomerase I and RAD52 protein in yeast reveals new facets of the mechanism of action of bisdioxopiperazine compounds.A camptothecin-resistant DNA topoisomerase I mutant exhibits altered sensitivities to other DNA topoisomerase poisons.From Lead to Drug Utilizing a Mannich Reaction: The Topotecan Story.RAFT-derived polymer-drug conjugates: poly(hydroxypropyl methacrylamide) (HPMA)-7-ethyl-10-hydroxycamptothecin (SN-38) conjugates.Synthesis of novel benzoxanthone analogues as non-Camptothecin topoisomerase I inhibitors.Synthesis of 9-(heteroarylmethylidene)amino derivatives of homocamptothecin with biological activities.Semisynthesis, cytotoxic activity, and oral availability of new lipophilic 9-substituted camptothecin derivatives.Topoisomerase I inhibitors and drug resistanceIn-vitro cytotoxicity, in-vivo biodistribution and anti-tumour effect of PEGylated liposomal topotecan.Characterization of a human small-cell lung cancer cell line resistant to a new water-soluble camptothecin derivative, DX-8951f.Hypersensitivity of NIH3T3 cells transformed by H-ras gene to DNA-topoisomerase-I inhibitors.
P2860
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P2860
Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Synthesis of water-soluble (am ...... rase I and antitumor activity.
@en
type
label
Synthesis of water-soluble (am ...... rase I and antitumor activity.
@en
prefLabel
Synthesis of water-soluble (am ...... rase I and antitumor activity.
@en
P2093
P356
P1476
Synthesis of water-soluble (am ...... rase I and antitumor activity.
@en
P2093
Caranfa MJ
Faucette LF
Gallagher G
Johnson RK
Kingsbury WD
P304
P356
10.1021/JM00105A017
P407
P577
1991-01-01T00:00:00Z