New functions for non-collagenous domains of human collagen type IV. Novel integrin ligands inhibiting angiogenesis and tumor growth in vivo.
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The 1.9-A crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-linkInteraction of endostatin with integrins implicated in angiogenesisPhysiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrinIdentification of amino acids essential for the antiangiogenic activity of tumstatin and its use in combination antitumor activityBreast cancer-induced angiogenesis: multiple mechanisms and the role of the microenvironmentMatricryptins Network with Matricellular Receptors at the Surface of Endothelial and Tumor CellsDevelopments in purification methods for obtaining and evaluation of collagen derived endogenous angioinhibitorsCollagen-derived matricryptins promote inhibitory nerve terminal formation in the developing neocortex.Crystal structure of NC1 domains. Structural basis for type IV collagen assembly in basement membranesExtracellular Matrix, a Hard Player in AngiogenesisMammalian collagen IVHuman alpha1 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by alpha1beta1 integrin.Deletion of the laminin alpha4 chain leads to impaired microvessel maturationHow matrix metalloproteinases regulate cell behaviorTetrastatin, the NC1 domain of the α4(IV) collagen chain: a novel potent anti-tumor matrikine.Recombinant non-collagenous domain of alpha2(IV) collagen causes involution of choroidal neovascularization by inducing apoptosis.Integrins as "functional hubs" in the regulation of pathological angiogenesisMatrilin-1 is an inhibitor of neovascularization.Inhibitory effects of arresten on bFGF-induced proliferation, migration, and matrix metalloproteinase-2 activation in mouse retinal endothelial cellsExtracellular matrix modulates angiogenesis in physiological and pathological conditions.Attenuation of diabetic retinopathy by enhanced inhibition of MMP-2 and MMP-9 using aspirin and minocycline in streptozotocin-diabetic ratsCharacterization of a non-fibrillar-related collagen in the mollusc Haliotis tuberculata and its biological activity on human dermal fibroblasts.The extracellular matrix can regulate vascular cell migration, proliferation, and survival: relationships to vascular disease.Angiogenesis and chronic kidney disease.Validation of Different Systems for Tumstatin Expression and its in-vitro and iv-vivo Activities.Order and disorder: the role of extracellular matrix in epithelial cancer.Identification of the alphavbeta3 integrin-interacting motif of betaig-h3 and its anti-angiogenic effect.A case of tumor betrayal: biphasic effects of TIMP-1 on Burkitt's lymphomaCollagens and collagen-related diseases.Regulation of Tumor Angiogenesis and Choroidal Neovascularization by Endogenous Angioinhibitors.Vascular wall extracellular matrix proteins and vascular diseasesTransforming growth factor-beta, basement membrane, and epithelial-mesenchymal transdifferentiation: implications for fibrosis in kidney disease.Halting angiogenesis by non-viral somatic gene therapy alleviates psoriasis and murine psoriasiform skin lesions.Arresten, a collagen-derived angiogenesis inhibitor, suppresses invasion of squamous cell carcinoma.ECM remodeling regulates angiogenesis: endothelial integrins look for new ligands.Basement membranes: cell scaffoldings and signaling platforms.Targeting the anthrax receptors, TEM-8 and CMG-2, for anti-angiogenic therapyInhibition of tumor-associated αvβ3 integrin regulates the angiogenic switch by enhancing expression of IGFBP-4 leading to reduced melanoma growth and angiogenesis in vivo.A reevaluation of integrins as regulators of angiogenesis.New functional roles for non-collagenous domains of basement membrane collagens
P2860
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P2860
New functions for non-collagenous domains of human collagen type IV. Novel integrin ligands inhibiting angiogenesis and tumor growth in vivo.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
New functions for non-collagen ...... esis and tumor growth in vivo.
@en
type
label
New functions for non-collagen ...... esis and tumor growth in vivo.
@en
prefLabel
New functions for non-collagen ...... esis and tumor growth in vivo.
@en
P2093
P356
P1476
New functions for non-collagen ...... nesis and tumor growth in vivo
@en
P2093
A Prestayko
E Petitclerc
M P Sarras
P C Brooks
Y Ninomiya
P304
P356
10.1074/JBC.275.11.8051
P407
P577
2000-03-01T00:00:00Z