Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53.
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Interaction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 TetramerAcetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentrationStructure and Kinetic Stability of the p63 Tetramerization DomainStructure of full-length p53 tumor suppressor probed by chemical cross-linking and mass spectrometry.An Integrated Mass Spectrometry Based Approach to Probe the Structure of the Full-Length Wild-Type Tetrameric p53 Tumor Suppressor.Counteracting chemical chaperone effects on the single-molecule α-synuclein structural landscape.Two p53 tetramers bind one consensus DNA response elementPathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseasesComputational analysis of signaling patterns in single cells.Propagation of aggregated p53: Cross-reaction and coaggregation vs. seeding.Surf the post-translational modification network of p53 regulationFirst-order rate-determining aggregation mechanism of p53 and its implicationsProtein oligomerization monitored by fluorescence fluctuation spectroscopy: self-assembly of rubisco activase.Low-level p53 expression changes transactivation rules and reveals superactivating sequences.Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.Activation and control of p53 tetramerization in individual living cellsDynamics of lesion processing by bacterial nucleotide excision repair proteinsExpanding the prion concept to cancer biology: dominant-negative effect of aggregates of mutant p53 tumour suppressorTP53 mutations in human cancer: database reassessment and prospects for the next decade.p53 oligomerization status modulates cell fate decisions between growth, arrest and apoptosis.Absolute quantification of protein copy number using a single-molecule-sensitive microarray.Real-Time Monitoring of Alzheimer's-Related Amyloid Aggregation via Probe Enhancement-Fluorescence Correlation Spectroscopy.An elegant way to quantitatively analyze oligomer formation in solution.Transactivation by low and high levels of human p53 reveals new physical rules of engagement and novel super-transactivation sequences.Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers.Oligomerization of the tetramerization domain of p53 probed by two- and three-color single-molecule FRET.Surface Plasmon Resonance Sensing of Biorecognition Interactions within the Tumor Suppressor p53 Network.The emergence of protein complexes: quaternary structure, dynamics and allostery. Colworth Medal Lecture.Cotranslational protein assembly imposes evolutionary constraints on homomeric proteins.R248Q mutation--Beyond p53-DNA binding.One-Dimensional Search Dynamics of Tumor Suppressor p53 Regulated by a Disordered C-Terminal Domain.Wild-type and cancer-related p53 proteins are preferentially degraded by MDM2 as dimers rather than tetramers.Cis and trans internucleosomal interactions of H3 and H4 tails in tetranucleosomes.Single-molecule diffusometry reveals the nucleotide-dependent oligomerization pathways of Nicotiana tabacum Rubisco activase.The p53 Pathway in GlioblastomaMapping the energy landscapes of supramolecular assembly by thermal hysteresisWild-type p53 oligomerizes more efficiently than p53 hot-spot mutants and overcomes mutant p53 gain-of-function via a "dominant-positive" mechanism
P2860
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P2860
Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Single-Molecule characterizati ...... a of the tumor suppressor p53.
@en
type
label
Single-Molecule characterizati ...... a of the tumor suppressor p53.
@en
prefLabel
Single-Molecule characterizati ...... a of the tumor suppressor p53.
@en
P2860
P356
P1476
Single-Molecule characterizati ...... a of the tumor suppressor p53.
@en
P2093
Fang Huang
Sridharan Rajagopalan
P2860
P304
P356
10.1093/NAR/GKQ800
P50
P577
2010-11-18T00:00:00Z