Identification of germline and somatic mutations affecting the retinoblastoma gene.
about
The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutationsTwo distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigenDysmorphic phenotype and neurological impairment in 22 retinoblastoma patients with constitutional cytogenetic 13q deletionThe ninth Gordon Hamilton-Fairley memorial lecture. Hereditary cancers: clues to mechanisms of carcinogenesis.Distal deletion of chromosome Ip in ductal carcinoma of the breast.Boy with bilateral retinoblastoma due to an unusual ring chromosome 13 with activation of a latent centromere.Recent advances in the gene map of inherited eye disorders: primary hereditary diseases of the retina, choroid, and vitreous.Application of PCR amplification of DNA from paraffin embedded tissue sections to linkage analysis in familial retinoblastoma.Genetic counselling in retinoblastoma: importance of ocular fundus examination of first degree relatives and linkage analysis.Mechanisms of p53 loss in human sarcomas.Analysis of retinoblastoma age incidence data using a fully stochastic cancer model.Molecular insight into medulloblastoma and central nervous system primitive neuroectodermal tumor biology from hereditary syndromes: a review.Coregulation of FANCA and BRCA1 in human cellsRole of the retinoblastoma gene in the initiation and progression of human cancerStructure of the human retinoblastoma gene.Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein.A Rb1 promoter variant with reduced activity contributes to osteosarcoma susceptibility in irradiated mice.Loss of the retinoblastoma susceptibility gene (RB1) is a frequent and early event in prostatic tumorigenesis.Patterns of missplicing caused by RB1 gene mutations in patients with retinoblastoma and association with phenotypic expression.Oncogenes and tumor-suppressor genes.Application of intragenic DNA probes in prenatal screening for retinoblastoma gene carriers in the United Kingdom.Linkage analysis of families with hereditary retinoblastoma: nonpenetrance of mutation, revealed by combined use of markers within and flanking the RB1 gene.Somatic mosaicism in a patient with bilateral retinoblastoma.Advantages of a next generation sequencing targeted approach for the molecular diagnosis of retinoblastoma.Mechanisms of oncogenesis in patients with familial retinoblastoma.Tumor suppressor genetics.How do retinoblastoma tumours form?Structural alterations of the RB1 gene in human soft tissue tumours.Molecular genetics in the pathology and diagnosis of retinoblastoma.A bipartite nuclear localization signal in the retinoblastoma gene product and its importance for biological activityHyperphosphorylation of the retinoblastoma gene product is determined by domains outside the simian virus 40 large-T-antigen-binding regionsMutations in the RB1 gene and their effects on transcription.Human papillomavirus type 16 E7 protein inhibits DNA binding by the retinoblastoma gene productTranscriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 geneNonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering.Correlation between retinoblastoma gene expression and differentiation in human testicular tumors.Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequencesFrequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cellsThe recessive mutational concept of oncogenesis.The retinoblastoma gene: its role in human malignancies.
P2860
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P2860
Identification of germline and somatic mutations affecting the retinoblastoma gene.
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
1988年论文
@zh
1988年论文
@zh-cn
name
Identification of germline and somatic mutations affecting the retinoblastoma gene.
@en
type
label
Identification of germline and somatic mutations affecting the retinoblastoma gene.
@en
prefLabel
Identification of germline and somatic mutations affecting the retinoblastoma gene.
@en
P2093
P356
P1433
P1476
Identification of germline and somatic mutations affecting the retinoblastoma gene.
@en
P2093
P304
P356
10.1126/SCIENCE.3175621
P407
P577
1988-09-01T00:00:00Z