Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure - Test2 - elhamkhani - TriplyDB

Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure

Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure

http://www.wikidata.org/entity/Q41866389

about

Kindlin-2 is required for myocyte elongation and is essential for myogenesis Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization The Role of Leucine-Rich Repeat Containing Protein 10 (LRRC10) in Dilated Cardiomyopathy Animal and in silico models for the study of sarcomeric cardiomyopathies ILK: a pseudokinase in the center stage of cell-matrix adhesion and signaling Arrhythmia caused by a Drosophila tropomyosin mutation is revealed using a novel optical coherence tomography instrument Paxillin and Focal Adhesion Kinase (FAK) Regulate Cardiac Contractility in the Zebrafish Heart Fermitins, the orthologs of mammalian Kindlins, regulate the development of a functional cardiac syncytium in Drosophila melanogaster Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy Osteopontin: At the cross-roads of myocyte survival and myocardial function Hic-5 is required for fetal gene expression and cytoskeletal organization of neonatal cardiac myocytes Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy c-Cbl ubiquitin ligase regulates focal adhesion protein turnover and myofibril degeneration induced by neutrophil protease cathepsin G Integrin-linked kinase in the vascular smooth muscle cell response to injury Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality Mammalian target of rapamycin is essential for cardiomyocyte survival and heart development in mice Integrin-linked kinase is a functional Mn2+-dependent protein kinase that regulates glycogen synthase kinase-3β (GSK-3beta) phosphorylation C3G overexpression promotes the survival of rat-derived H9C2 cardiomyocytes by p-ERK1/2.Elevated expression of C3G protein in the peri-infarct myocardium of rats.Integrins and integrin-associated proteins in the cardiac myocyte.Phosphoinositide-dependent kinase 1 and mTORC2 synergistically maintain postnatal heart growth and heart function in mice.A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging.The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!Expression of integrin-linked kinase improves cardiac function in a swine model of myocardial infarction Significance of thymosin β4 and implication of PINCH-1-ILK-α-parvin (PIP) complex in human dilated cardiomyopathy Cardiac Z-disc signaling network.Increased expression of integrin-linked kinase improves cardiac function and decreases mortality in dilated cardiomyopathy model of rats.Adenovirus-mediated overexpression of cardiac troponin I-interacting kinase promotes cardiomyocyte hypertrophy.ILK induces cardiomyogenesis in the human heart.ILK mediates the effects of strain on intestinal epithelial wound closure Mechanosensing and Regulation of Cardiac Function.Dietary fatty acids alter left ventricular myocardial gene expression in Wistar rats.Functional Role of mTORC2 versus Integrin-Linked Kinase in Mediating Ser473-Akt Phosphorylation in PTEN-Negative Prostate and Breast Cancer Cell Lines.Vinculin and talin: focus on the myocardium Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury Platelet endothelial cell adhesion molecule-1 mediates endothelial-cardiomyocyte communication and regulates cardiac function.Integrin-linked kinase regulates the rate of platelet activation and is essential for the formation of stable thrombi.Mechanotransduction in cardiac hypertrophy and failure.The extracellular matrix and insulin resistance.β1 integrin gene excision in the adult murine cardiac myocyte causes defective mechanical and signaling responses.

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P2860

Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure

http://www.wikidata.org/entity/Q41866389

description

2006 nî lūn-bûn

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Targeted ablation of ILK from ...... and spontaneous heart failure

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P2093

Donald E White

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Jean-Claude Tardif

http://www.w3.org/2001/XMLSchema#string

Pierre Coutu

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René St Arnaud

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Shoukat Dedhar

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William J Muller

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Yan-Fen Shi

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P2860

A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading

Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase

Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase

The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy

The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells

A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343

The failing heart

Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair

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10.1101/GAD.1458906

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17

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20

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6839225

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16951252

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1560410

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