An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2.
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Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase systemNew vitamin D analogs as potential therapeutics in melanomaSequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kappaB activity by increasing IkappaB alpha levels in human keratinocytes.Novel vitamin D analogs as potential therapeutics: metabolism, toxicity profiling, and antiproliferative activity.RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D.Purified mouse CYP27B1 can hydroxylate 20,23-dihydroxyvitamin D3, producing 1alpha,20,23-trihydroxyvitamin D3, which has altered biological activitySensing the environment: regulation of local and global homeostasis by the skin's neuroendocrine system.Lumisterol is metabolized by CYP11A1: discovery of a new pathwayNeuroendocrinology of the skin: An overview and selective analysis20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiationPathways and products for the metabolism of vitamin D3 by cytochrome P450scc20-Hydroxyvitamin D2 is a noncalcemic analog of vitamin D with potent antiproliferative and prodifferentiation activities in normal and malignant cells.Vitamin D and skin cancer.Production of 22-hydroxy metabolites of vitamin d3 by cytochrome p450scc (CYP11A1) and analysis of their biological activities on skin cellsMetabolism of 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3 by rat and human CYP24A1Antitumor effects of vitamin D analogs on hamster and mouse melanoma cell lines in relation to melanin pigmentation.Human cytochrome P450scc (CYP11A1) catalyzes epoxide formation with ergosterol.Differential antitumor effects of vitamin D analogues on colorectal carcinoma in culture.In vivo evidence for a novel pathway of vitamin D₃ metabolism initiated by P450scc and modified by CYP27B1.On the role of skin in the regulation of local and systemic steroidogenic activities.Total synthesis of biologically active 20S-hydroxyvitamin D3.Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes20S-hydroxyvitamin D3, noncalcemic product of CYP11A1 action on vitamin D3, exhibits potent antifibrogenic activity in vivoNovel activities of CYP11A1 and their potential physiological significance.Differential expression of HPA axis homolog in the skin.Hydroxylation of CYP11A1-derived products of vitamin D3 metabolism by human and mouse CYP27B1.Steroidogenic enzyme Cyp11a1 regulates Type 2 CD8+ T cell skewing in allergic lung disease.Melanocyte receptors: clinical implications and therapeutic relevance.Metabolism of 1alpha-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1alpha,20-dihydroxyvitamin D3.Cytochromes p450 and skin cancer: role of local endocrine pathways.Adaptive evolution of mammalian aromatases: lessons from Suiformes.Skin as an endocrine organ: implications for its functionThe osteogenic transcription factor runx2 controls genes involved in sterol/steroid metabolism, including CYP11A1 in osteoblasts.Novel vitamin D photoproducts and their precursors in the skin.Isotope-Labeling Studies Support the Electrophilic Compound I Iron Active Species, FeO(3+), for the Carbon-Carbon Bond Cleavage Reaction of the Cholesterol Side-Chain Cleavage Enzyme, Cytochrome P450 11A1Pediatric Hypovitaminosis D: Molecular Perspectives and Clinical Implications.In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland.The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions.Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation.
P2860
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P2860
An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
An alternative pathway of vita ...... and 17,20-dihydroxyvitamin D2.
@en
type
label
An alternative pathway of vita ...... and 17,20-dihydroxyvitamin D2.
@en
prefLabel
An alternative pathway of vita ...... and 17,20-dihydroxyvitamin D2.
@en
P2093
P2860
P50
P1433
P1476
An alternative pathway of vita ...... and 17,20-dihydroxyvitamin D2
@en
P2093
Blazej Zbytek
Jacobo Wortsman
P2860
P304
P356
10.1111/J.1742-4658.2006.05302.X
P407
P577
2006-07-01T00:00:00Z