TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells.
about
Protein kinase C signaling and cell cycle regulationFunctional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survivalGRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-γ1 Activation and Cytokine Production.Primary murine CD4+ T cells fail to acquire the ability to produce effector cytokines when active Ras is present during Th1/Th2 differentiation.Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration.Regulation of Ras signal transduction during T cell development and activation.Activation of extracellular signal-regulated kinase but not of p38 mitogen-activated protein kinase pathways in lymphocytes requires allosteric activation of SOS.Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells.Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells.Redox regulation of T-cell receptor signaling.PBMC activation via the ERK and STAT signaling pathways enhances the anti-tumor activity of Staphylococcal enterotoxin A.Sos1 disruption impairs cellular proliferation and viability through an increase in mitochondrial oxidative stress in primary MEFs.Grb2 Is Important for T Cell Development, Th Cell Differentiation, and Induction of Experimental Autoimmune Encephalomyelitis.MiR-148a impairs Ras/ERK signaling in B lymphocytes by targeting SOS proteinsSos1 regulates sustained TCR-mediated Erk activation.Loss of RASGRP1 in humans impairs T-cell expansion leading to Epstein-Barr virus susceptibility.Grb2 and GRAP connect the B cell antigen receptor to Erk MAP kinase activation in human B cells.Inherited Immunodeficiencies With High Predisposition to Epstein–Barr Virus-Driven Lymphoproliferative Diseases.
P2860
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P2860
TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells.
@en
type
label
TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells.
@en
prefLabel
TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells.
@en
P2093
P2860
P356
P1433
P1476
TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells.
@en
P2093
Bhavani S Kowtharapu
Boerge Arndt
Burkhart Schraven
James C Stone
Luca Simeoni
Mateusz Poltorak
Nicole Warnecke
P2860
P304
P356
10.1038/EMBOR.2012.17
P577
2012-04-01T00:00:00Z