Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements.
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Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterolHuman SREBP1c expression in liver is directly regulated by peroxisome proliferator-activated receptor alpha (PPARalpha)24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injuryInsulin induces human acyl-coenzyme A: cholesterol acyltransferase1 gene expression via MAP kinases and CCAAT/enhancer-binding protein αDocosahexaneoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathwaysInsulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesiclesHmgcr in the corpus allatum controls sexual dimorphism of locomotor activity and body size via the insulin pathway in Drosophila.Insulin enhances the biogenesis of nuclear sterol regulatory element-binding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its dissociation from SREBP cleavage-activating protein (SCAP).SREBP-1c complex.Dysregulation of sterol regulatory element binding protein-1c in livers of morbidly obese women is associated with altered suppressor of cytokine signaling-3 and signal transducer and activator of transcription-1 signaling.Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets.Essential fatty acids as functional components of foods- a reviewBone muscle crosstalk targets muscle regeneration pathway regulated by core circadian transcriptional repressors DEC1 and DEC2.Different adipose depots: their role in the development of metabolic syndrome and mitochondrial response to hypolipidemic agents.Stra13/DEC1 and DEC2 inhibit sterol regulatory element binding protein-1c in a hypoxia-inducible factor-dependent mechanismHepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosisMicroRNA hsa-miR-613 targets the human LXRα gene and mediates a feedback loop of LXRα autoregulation.Mechanism of AMPK suppression of LXR-dependent Srebp-1c transcriptionInsulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c.The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance.Evidence coupling increased hexosamine biosynthesis pathway activity to membrane cholesterol toxicity and cortical filamentous actin derangement contributing to cellular insulin resistance.New insights into the mechanism of low high-density lipoprotein cholesterol in obesitySelective inhibition of liver X receptor α-mediated lipogenesis in primary hepatocytes by licochalcone AmPGES-2 deletion remarkably enhances liver injury in streptozotocin-treated mice via induction of GLUT2p38 mitogen-activated protein kinase and liver X receptor-α mediate the leptin effect on sterol regulatory element binding protein-1c expression in hepatic stellate cellsFoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1c.Insulin Dissociates the Effects of Liver X Receptor on Lipogenesis, Endoplasmic Reticulum Stress, and Inflammation.Hexosamine biosynthesis impairs insulin action via a cholesterolgenic responseE4BP4 is an insulin-induced stabilizer of nuclear SREBP-1c and promotes SREBP-1c-mediated lipogenesis.Hexosamine biosynthesis pathway flux contributes to insulin resistance via altering membrane phosphatidylinositol 4,5-bisphosphate and cortical filamentous actinGRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice.N-3 polyunsaturated fatty acids suppress insulin-induced SREBP-1c transcription via reduced trans-activating capacity of LXRalpha.Cilostazol inhibits insulin-stimulated expression of sterol regulatory binding protein-1c via inhibition of LXR and Sp1NF-Y and the transcriptional activation of CCAAT promoters.Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle.Insulin induction of glucokinase and fatty acid synthase in hepatocytes: analysis of the roles of sterol-regulatory-element-binding protein-1c and liver X receptor.Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs.cAMP response element binding protein H mediates fenofibrate-induced suppression of hepatic lipogenesis.Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin.Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell lineFibroblast growth factor-19, a novel factor that inhibits hepatic fatty acid synthesis
P2860
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P2860
Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Insulin activates the rat ster ...... and NF-Y cis-acting elements.
@en
Insulin activates the rat ster ...... and NF-Y cis-acting elements.
@nl
type
label
Insulin activates the rat ster ...... and NF-Y cis-acting elements.
@en
Insulin activates the rat ster ...... and NF-Y cis-acting elements.
@nl
prefLabel
Insulin activates the rat ster ...... and NF-Y cis-acting elements.
@en
Insulin activates the rat ster ...... and NF-Y cis-acting elements.
@nl
P2093
P2860
P356
P1433
P1476
Insulin activates the rat ster ...... and NF-Y cis-acting elements.
@en
P2093
Edwards A Park
Henry G Wilcox
Lauren M Cagen
Marshall B Elam
Rajendra Raghow
Xiong Deng
P2860
P304
P356
10.1042/BJ20040162
P407
P577
2005-01-01T00:00:00Z