about
High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions.Online chemical modeling environment (OCHEM): web platform for data storage, model development and publishing of chemical informationAnalysis of Iterative Screening with Stepwise Compound Selection Based on Novartis In-house HTS Data.Data-Driven Derivation of an "Informer Compound Set" for Improved Selection of Active Compounds in High-Throughput Screening.Classifying large chemical data sets: using a regularized potential function method.Recent trends and observations in the design of high-quality screening collections.Computational methods for early predictive safety assessment from biological and chemical data.Activity-aware clustering of high throughput screening data and elucidation of orthogonal structure-activity relationships.Melting point prediction employing k-nearest neighbor algorithms and genetic parameter optimization.A novel hybrid ultrafast shape descriptor method for use in virtual screening.In vitro models for processes involved in intestinal absorption.Rethinking molecular similarity: comparing compounds on the basis of biological activity.Multidimensional pooled shRNA screens in human THP-1 cells identify candidate modulators of macrophage polarization.Evidence-Based and Quantitative Prioritization of Tool Compounds in Phenotypic Drug Discovery.Toxicological relationships between proteins obtained from protein target predictions of large toxicity databases.A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space.Simultaneous feature selection and parameter optimisation using an artificial ant colony: case study of melting point prediction.Determination of minimal transcriptional signatures of compounds for target prediction.Predicting the mechanism of phospholipidosis.Causal Network Models for Predicting Compound Targets and Driving Pathways in Cancer.The multidimensional perturbation value: a single metric to measure similarity and activity of treatments in high-throughput multidimensional screens.Ligand-target prediction using Winnow and naive Bayesian algorithms and the implications of overall performance statistics.Total synthesis of (+)-crocacin D.How to winnow actives from inactives: introducing molecular orthogonal sparse bigrams (MOSBs) and multiclass Winnow.Why are some properties more difficult to predict than others? A study of QSPR models of solubility, melting point, and Log P.Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy.Corrigendum: The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi.Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia.Online chemical modeling environment (OCHEM): web platform for data storage, model development and publishing of chemical informationScreening of Intestinal Crypt Organoids: A Simple Readout for Complex BiologyComputational toxicology: an overview of the sources of data and of modelling methodsTranscriptomic analysis reveals reduced transcriptional activity in the malaria parasite during progression into dormancyIRF2 is a master regulator of human keratinocyte stem cell fateYAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver InjuryCellSIUS provides sensitive and specific detection of rare cell populations from complex single-cell RNA-seq dataFarnesoid X Receptor Agonism, Acetyl-Coenzyme A Carboxylase Inhibition, and Back Translation of Clinically Observed Endpoints of De Novo Lipogenesis in a Murine NASH Model
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Florian Nigsch
@ast
Florian Nigsch
@en
Florian Nigsch
@es
Florian Nigsch
@nl
Florian Nigsch
@sl
type
label
Florian Nigsch
@ast
Florian Nigsch
@en
Florian Nigsch
@es
Florian Nigsch
@nl
Florian Nigsch
@sl
prefLabel
Florian Nigsch
@ast
Florian Nigsch
@en
Florian Nigsch
@es
Florian Nigsch
@nl
Florian Nigsch
@sl
P106
P21
P2456
P31
P496
0000-0002-2919-8749