High-throughput method development for sensitive, accurate, and reproducible quantification of therapeutic monoclonal antibodies in tissues using orthogonal array optimization and nano liquid chromatography/selected reaction monitoring mass spectrom

High-throughput method development for sensitive, accurate, and reproducible quantification of therapeutic monoclonal antibodies in tissues using orthogonal array optimization and nano liquid chromatography/selected reaction monitoring mass spectrom

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http://www.wikidata.org/entity/Q42118236

Q42118236

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Ion-current-based proteomic profiling of the retina in a rat model of Smith-Lemli-Opitz syndrome.Large-scale, ion-current-based proteomics investigation of bronchoalveolar lavage fluid in chronic obstructive pulmonary disease patients Quantitative proteomics in cardiovascular research: global and targeted strategies Toward sensitive and accurate analysis of antibody biotherapeutics by liquid chromatography coupled with mass spectrometry.Targeted Proteomics Enables Simultaneous Quantification of Folate Receptor Isoforms and Potential Isoform-based Diagnosis in Breast Cancer.Impact of Sample Matrix on Accuracy of Peptide Quantification: Assessment of Calibrator and Internal Standard Selection and Method Validation.ADME of monoclonal antibody biotherapeutics: knowledge gaps and emerging tools.Characterization of immunoglobulin by mass spectrometry with applications for the clinical laboratory.Application and challenges in using LC-MS assays for absolute quantitative analysis of therapeutic proteins in drug discovery.Quantitation of human peptides and proteins via MS: review of analytically validated assays.Applications of low-flow LC-SRM for the analysis of large molecules in pharmaceutical R&D.Antibody-free workflows for protein quantification by LC-MS/MS.Quantitative MS analysis of therapeutic mAbs and their glycosylation for pharmacokinetics study.Effects of calibration approaches on the accuracy for LC-MS targeted quantification of therapeutic protein.Qualitative and quantitative characterization of protein biotherapeutics with liquid chromatography mass spectrometry.Proteomic analysis reveals diverse classes of arginine methylproteins in mitochondria of trypanosomes.Quantification of human mAbs in mouse tissues using generic affinity enrichment procedures and LC-MS detection.Sensitive, High-Throughput, and Robust Trapping-Micro-LC-MS Strategy for the Quantification of Biomarkers and Antibody Biotherapeutics.Novel strategy using tryptic peptide immunoaffinity-based LC-MS/MS to quantify denosumab in monkey serum.Key considerations for LC-MS analysis of protein biotherapeutics in tissues.Quantitative LC/ESI-SRM/MS of antibody biopharmaceuticals: use of a homologous antibody as an internal standard and three-step method development.A fluorometric microarray with ZnO substrate-enhanced fluorescence and suppressed "coffee-ring" effects for fluorescence immunoassays.

P2860

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P2860

High-throughput method development for sensitive, accurate, and reproducible quantification of therapeutic monoclonal antibodies in tissues using orthogonal array optimization and nano liquid chromatography/selected reaction monitoring mass spectrom

Item

http://www.wikidata.org/entity/Q42118236

description

2012 nî lūn-bûn

@nan

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

2012年论文

@zh

2012年论文

@zh-cn

name

High-throughput method develop ...... ction monitoring mass spectrom

@en

High-throughput method develop ...... ction monitoring mass spectrom

@nl

type

Item

label

High-throughput method develop ...... ction monitoring mass spectrom

@en

High-throughput method develop ...... ction monitoring mass spectrom

@nl

prefLabel

High-throughput method develop ...... ction monitoring mass spectrom

@en

High-throughput method develop ...... ction monitoring mass spectrom

@nl

P1476

High-throughput method develop ...... ction monitoring mass spectrom

@en

P2093

Joseph P Balthasar

http://www.w3.org/2001/XMLSchema#string

Jun Qu

http://www.w3.org/2001/XMLSchema#string

Lipeng Dai

http://www.w3.org/2001/XMLSchema#string

Lubna Abuqayyas

http://www.w3.org/2001/XMLSchema#string

Xiaotao Duan

http://www.w3.org/2001/XMLSchema#string

P2860

Accurate localization and relative quantification of arginine methylation using nanoflow liquid chromatography coupled to electron transfer dissociation and orbitrap mass spectrometry

Protein quantification by MALDI-selected reaction monitoring mass spectrometry using sulfonate derivatized peptides.

Combinatorial peptide ligand library treatment followed by a dual-enzyme, dual-activation approach on a nanoflow liquid chromatography/orbitrap/electron transfer dissociation system for comprehensive analysis of swine plasma proteome.

A rapid, reproducible, on-the-fly orthogonal array optimization method for targeted protein quantification by LC/MS and its application for accurate and sensitive quantification of carbonyl reductases in human liver.

Quantitative improvements in peptide recovery at elevated chromatographic temperatures from microcapillary liquid chromatography-mass spectrometry analyses of brain using selected reaction monitoring.

Monoclonal antibodies: versatile platforms for cancer immunotherapy.

Effect of collision energy optimization on the measurement of peptides by selected reaction monitoring (SRM) mass spectrometry.

Quantitative mass spectrometric multiple reaction monitoring assays for major plasma proteins.

Bioanalytical approaches to quantify "total" and "free" therapeutic antibodies and their targets: technical challenges and PK/PD applications over the course of drug development.

Antibody-based therapeutics to watch in 2011.

P304

4373-4382

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1021/AC2034166

http://www.w3.org/2001/XMLSchema#string

P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P577

2012-04-27T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

224808489

http://www.w3.org/2001/XMLSchema#string

P698

22519810

http://www.w3.org/2001/XMLSchema#string

P921

reproducibility

antibody

P932

3352998

http://www.w3.org/2001/XMLSchema#string

High-throughput method development for sensitive, accurate, and reproducible quantification of therapeutic monoclonal antibodies in tissues using orthogonal array optimization and nano liquid chromatography/selected reaction monitoring mass spectrom

about

P2860

P2860

High-throughput method development for sensitive, accurate, and reproducible quantification of therapeutic monoclonal antibodies in tissues using orthogonal array optimization and nano liquid chromatography/selected reaction monitoring mass spectrom

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P577

P5875

P698

P921

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P577

P5875

P698

P921

P932