about
Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactionsStimulation of NSF ATPase activity by alpha-SNAP is required for SNARE complex disassembly and exocytosisUsing C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseasesNMR Structure of Hsp12, a Protein Induced by and Required for Dietary Restriction-Induced Lifespan Extension in YeastPhosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis.Biochemical analysis of the Saccharomyces cerevisiae SEC18 gene product: implications for the molecular mechanism of membrane fusion.Suppression of homologous recombination by the Saccharomyces cerevisiae linker histone.Physiological regulation of Munc18/nSec1 phosphorylation on serine-313Analysis of the interacting partners of the neuronal calcium-binding proteins L-CaBP1, hippocalcin, NCS-1 and neurocalcin deltaControl of membrane fusion dynamics during regulated exocytosis.Calorie restriction reduces rDNA recombination independently of rDNA silencing.Caenorhabditis elegans dnj-14, the orthologue of the DNAJC5 gene mutated in adult onset neuronal ceroid lipofuscinosis, provides a new platform for neuroprotective drug screening and identifies a SIR-2.1-independent action of resveratrol.Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expressionAnalysis of the brain palmitoyl-proteome using both acyl-biotin exchange and acyl-resin-assisted capture methods.A direct inhibitory role for the Rab3-specific effector, Noc2, in Ca2+-regulated exocytosis in neuroendocrine cells.A systematic analysis of protein palmitoylation in Caenorhabditis elegansStructure-function study of mammalian Munc18-1 and C. elegans UNC-18 implicates domain 3b in the regulation of exocytosis.The functions of Munc18-1 in regulated exocytosis.Tying everything together: the multiple roles of cysteine string protein (CSP) in regulated exocytosis.Membrane traffic: controlling membrane fusion by modifying NSF.PKC-2 phosphorylation of UNC-18 Ser322 in AFD neurons regulates temperature dependency of locomotion.Expression profile of a Caenorhabditis elegans model of adult neuronal ceroid lipofuscinosis reveals down regulation of ubiquitin E3 ligase components.Calcium-dependent regulation of exocytosis.Phosphomimetic mutation of Ser-187 of SNAP-25 increases both syntaxin binding and highly Ca2+-sensitive exocytosis.UNC-18 modulates ethanol sensitivity in Caenorhabditis elegans.Presynaptic targets for acute ethanol sensitivity.Caenorhabditis elegans: a useful tool to decipher neurodegenerative pathways.Neurotransmitter release mechanisms studied in Caenorhabditis elegans.Epilepsy research methods update: Understanding the causes of epileptic seizures and identifying new treatments using non-mammalian model organisms.Yeast Nhp6A/B and mammalian Hmgb1 facilitate the maintenance of genome stability.Cysteine string protein (CSP) and its role in preventing neurodegeneration.Protein kinase B/Akt is a novel cysteine string protein kinase that regulates exocytosis release kinetics and quantal size.New links between SOD1 and metabolic dysfunction from a yeast model of amyotrophic lateral sclerosis.Phosphorylation of Cysteine String Protein Triggers a Major Conformational SwitchS-nitrosylation of syntaxin 1 at Cys(145) is a regulatory switch controlling Munc18-1 binding.Phosphorylation-dependent interaction of the synaptic vesicle proteins cysteine string protein and synaptotagmin I.A synthetic peptide of the N-terminus of ADP-ribosylation factor (ARF) inhibits regulated exocytosis in adrenal chromaffin cells.A random mutagenesis approach to isolate dominant-negative yeast sec1 mutants reveals a functional role for domain 3a in yeast and mammalian Sec1/Munc18 proteins.Identification of a key domain in annexin and 14-3-3 proteins that stimulate calcium-dependent exocytosis in permeabilized adrenal chromaffin cells.Distinct effects of alpha-SNAP, 14-3-3 proteins, and calmodulin on priming and triggering of regulated exocytosis.
P50
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P50
description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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name
Alan Morgan
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Alan Morgan
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Alan Morgan
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Alan Morgan
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type
label
Alan Morgan
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Alan Morgan
@en
Alan Morgan
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Alan Morgan
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prefLabel
Alan Morgan
@ast
Alan Morgan
@en
Alan Morgan
@es
Alan Morgan
@nl
P106
P1153
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P21
P31
P496
0000-0002-0346-1289