Structural dynamics associated with intermediate formation in an archetypal conformational disease.
about
Molecular mechanisms of disease-causing missense mutationsAFM Imaging Reveals Topographic Diversity of Wild Type and Z Variant Polymers of Human α1-Proteinase InhibitorAmphitrite: A program for processing travelling wave ion mobility mass spectrometry data.Altered native stability is the dominant basis for susceptibility of α1-antitrypsin mutants to polymerization.Therapeutic targeting of misfolding and conformational change in α1-antitrypsin deficiency.Smoothing a rugged protein folding landscape by sequence-based redesign.An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour.Twenty years of polymers: a personal perspective on alpha-1 antitrypsin deficiency.An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein.An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1 -antitrypsin upon ligand binding.Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway.
P2860
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P2860
Structural dynamics associated with intermediate formation in an archetypal conformational disease.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Structural dynamics associated ...... etypal conformational disease.
@en
Structural dynamics associated ...... etypal conformational disease.
@nl
type
label
Structural dynamics associated ...... etypal conformational disease.
@en
Structural dynamics associated ...... etypal conformational disease.
@nl
prefLabel
Structural dynamics associated ...... etypal conformational disease.
@en
Structural dynamics associated ...... etypal conformational disease.
@nl
P2093
P2860
P50
P1433
P1476
Structural dynamics associated ...... hetypal conformational disease
@en
P2093
Anathe O M Patschull
David A Lomas
Géraldine R Lévy
John Christodoulou
John Kirkpatrick
Lakshmi Segu
Lisa D Cabrita
Marian Hill
Mun Peak Nyon
Noor Kalsheker
P2860
P304
P356
10.1016/J.STR.2012.01.012
P577
2012-03-01T00:00:00Z