Inhibition of phosphodiesterase-3 by levosimendan is sufficient to account for its inotropic effect in failing human heart.
about
The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardiumTargeting the sarcomere to correct muscle functionExploration of Pharmacophore in Chrysosplenol C as Activator in Ventricular Myocyte Contraction.New medical therapies for heart failure.β-adrenergic receptor signalling and its functional consequences in the diseased heart.Probing the mechanism of cardiovascular drugs using a covalent levosimendan analog.Septic cardiomyopathy in rat LPS-induced endotoxemia: relative contribution of cellular diastolic Ca(2+) removal pathways, myofibrillar biomechanics properties and action of the cardiotonic drug levosimendan.Does levosimendan act as Ca(2+) sensitizer or PDE3 inhibitor?Direct Myosin Activation by Omecamtiv Mecarbil for Heart Failure with Reduced Ejection Fraction.Effects of Combined Milrinone and Levosimendan Treatment on Systolic and Diastolic Function During Postischemic Myocardial Dysfunction in a Porcine Model.
P2860
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P2860
Inhibition of phosphodiesterase-3 by levosimendan is sufficient to account for its inotropic effect in failing human heart.
description
2014 nî lūn-bûn
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2014年の論文
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2014年学术文章
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2014年学术文章
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name
Inhibition of phosphodiesteras ...... effect in failing human heart.
@en
Inhibition of phosphodiesteras ...... effect in failing human heart.
@nl
type
label
Inhibition of phosphodiesteras ...... effect in failing human heart.
@en
Inhibition of phosphodiesteras ...... effect in failing human heart.
@nl
prefLabel
Inhibition of phosphodiesteras ...... effect in failing human heart.
@en
Inhibition of phosphodiesteras ...... effect in failing human heart.
@nl
P2093
P2860
P356
P1476
Inhibition of phosphodiesteras ...... effect in failing human heart.
@en
P2093
G Ø Andersen
O Orstavik
T Skomedal
P2860
P304
P356
10.1111/BPH.12647
P407
P577
2014-12-01T00:00:00Z