Optimization of gene expression through divergent mutational paths.
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Convergent evolution of hyperswarming leads to impaired biofilm formation in pathogenic bacteriaTranshydrogenase promotes the robustness and evolvability of E. coli deficient in NADPH productionMetabolomics Revealed an Association of Metabolite Changes and Defective Growth in Methylobacterium extorquens AM1 Overexpressing ecm during Growth on MethanolParallel and Divergent Evolutionary Solutions for the Optimization of an Engineered Central Metabolism in Methylobacterium extorquens AM1Good codons, bad transcript: large reductions in gene expression and fitness arising from synonymous mutations in a key enzymeISQuest: finding insertion sequences in prokaryotic sequence fragment data.Recovering from a bad start: rapid adaptation and tradeoffs to growth below a threshold density.FREQ-Seq: a rapid, cost-effective, sequencing-based method to determine allele frequencies directly from mixed populationsEvolution after introduction of a novel metabolic pathway consistently leads to restoration of wild-type physiology.Development of an optimized medium, strain and high-throughput culturing methods for Methylobacterium extorquens.A novel pair of inducible expression vectors for use in Methylobacterium extorquens.Evolutionary tuning of protein expression levels of a positively autoregulated two-component system.Laboratory divergence of Methylobacterium extorquens AM1 through unintended domestication and past selection for antibiotic resistanceMapping the fitness landscape of gene expression uncovers the cause of antagonism and sign epistasis between adaptive mutations.Genetic and phenotypic comparison of facultative methylotrophy between Methylobacterium extorquens strains PA1 and AM1.Parallel Mutations Result in a Wide Range of Cooperation and Community Consequences in a Two-Species Bacterial ConsortiumEvolutionary adaptation after crippling cell polarization follows reproducible trajectories.Hierarchical mutational events compensate for glutamate auxotrophy of a Bacillus subtilis gltC mutant.Synchronous waves of failed soft sweeps in the laboratory: remarkably rampant clonal interference of alleles at a single locus.Large-Effect Beneficial Synonymous Mutations Mediate Rapid and Parallel Adaptation in a Bacterium.Experimental Horizontal Gene Transfer of Methylamine Dehydrogenase Mimics Prevalent Exchange in Nature and Overcomes the Methylamine Growth Constraints Posed by the Sub-Optimal N-Methylglutamate PathwayMethylobacterium extorquens: methylotrophy and biotechnological applications.The dynamics of diverse segmental amplifications in populations of Saccharomyces cerevisiae adapting to strong selection.Love the one you're with: replicate viral adaptations converge on the same phenotypic change.Methenyl-Dephosphotetrahydromethanopterin Is a Regulatory Signal for Acclimation to Changes in Substrate Availability in Methylobacterium extorquens AM1.Phenotypic and genotypic convergences are influenced by historical contingency and environment in yeast.Transposable Elements Mediate Adaptive Debilitation of Flagella in Experimental Escherichia coli Populations.OASIS: an automated program for global investigation of bacterial and archaeal insertion sequences.Sign epistasis limits evolutionary trade-offs at the confluence of single- and multi-carbon metabolism in Methylobacterium extorquens AM1.A two-step evolutionary process establishes a non-native vitamin B6 pathway in Bacillus subtilis.Experimental Design, Population Dynamics, and Diversity in Microbial Experimental Evolution
P2860
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P2860
Optimization of gene expression through divergent mutational paths.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Optimization of gene expression through divergent mutational paths.
@en
Optimization of gene expression through divergent mutational paths.
@nl
type
label
Optimization of gene expression through divergent mutational paths.
@en
Optimization of gene expression through divergent mutational paths.
@nl
prefLabel
Optimization of gene expression through divergent mutational paths.
@en
Optimization of gene expression through divergent mutational paths.
@nl
P2860
P1433
P1476
Optimization of gene expression through divergent mutational paths
@en
P2093
Christopher J Marx
P2860
P304
P356
10.1016/J.CELREP.2011.12.003
P577
2012-02-02T00:00:00Z