about
Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70.Investigating Apoptozole as a Chemical Probe for HSP70 InhibitionA fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.Lysine-Targeting Covalent Inhibitors.Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines.Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9.N-N bond-forming cyclization for the one-pot synthesis of N-aryl[3,4-d]pyrazolopyrimidines.An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56A temporary stereocentre approach for the asymmetric synthesis of chiral cyclopropane-carboxaldehydes.Synthesis of (+)-DGDP and (-)-7-epialexine.A novel strategy for the asymmetric synthesis of chiral cyclopropane carboxaldehydes.Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen.Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex.Efficient asymmetric synthesis of chiral hydroxy-gamma-butyrolactones.Privileged Structures and Polypharmacology within and between Protein Families.Stereoselective synthesis of (E)-trisubstituted alpha,beta-unsaturated amides and acidsFlexible strategy for the synthesis of pyrrolizidine alkaloidsAsymmetric synthesis of chiral δ-lactones containing multiple contiguous stereocentersKinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72
P50
Q27704725-E7ECA2EE-5B2B-4F64-A702-E967529C4F68Q28550180-BCA75AA6-D730-4B0D-AC24-85F0BB94C5EEQ30372203-BBFC2BD8-071F-462B-9EC6-43BE7EF88E2AQ38635726-9303179C-7EA5-4962-BB81-2026AEA91111Q38982273-00AFDFC9-51A1-401B-B4AB-18A9E9D166BEQ41292799-FB58CA57-797D-44E8-BFFA-B97E7E78A1DFQ42227466-6255E722-9B75-47C9-AFE6-F8EA55840244Q42289932-3952F214-A77C-413E-8F00-D005E7B30C15Q43292697-383AD56A-BE6B-475A-A8BD-DB0BA3F3C537Q46309167-CBCED7C8-58AA-4730-AD22-85689E5B33A7Q46475130-437F0418-6AD9-4C28-9FFF-C1D02ED3C476Q47294366-43F902CA-A7E0-4F87-B915-D2BFA112CE3AQ48125728-376B37D5-75DE-45CF-90A4-02F0661CDCACQ48237303-BACFE88C-BDBD-45F6-A79A-B42474345873Q50591389-F2E5E20B-9A72-43CA-8542-F6C75AF6455AQ64885983-D2AC1257-6B6F-4746-BA6C-B280F2868203Q81267544-96BF4748-2D94-4C5D-855B-C42602CFC170Q81660910-E9DF60B9-4A20-42CE-A669-BAA0F6A8F487Q84357683-A0882C86-6F6C-4DF1-B6A4-4C235B4ACE42Q91278640-CFC8C61C-6103-4E18-8F45-939094AB67DE
P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Matthew D Cheeseman
@ast
Matthew D Cheeseman
@en
Matthew D Cheeseman
@es
Matthew D Cheeseman
@nl
Matthew D Cheeseman
@sl
type
label
Matthew D Cheeseman
@ast
Matthew D Cheeseman
@en
Matthew D Cheeseman
@es
Matthew D Cheeseman
@nl
Matthew D Cheeseman
@sl
altLabel
Matt Cheeseman
@en
prefLabel
Matthew D Cheeseman
@ast
Matthew D Cheeseman
@en
Matthew D Cheeseman
@es
Matthew D Cheeseman
@nl
Matthew D Cheeseman
@sl
P108
P1053
Q-9527-2016
P106
P2038
Matthew_Cheeseman
P21
P31
P3829
P3835
matt-cheeseman
P496
0000-0003-1121-6985