about
Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1Recognition of the DNA minor groove by thiazotropsin analoguesRanking ligand affinity for the DNA minor groove by experiment and simulation.Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy propertiesDesigning anti-inflammatory drugs from parasitic worms: a synthetic small molecule analogue of the Acanthocheilonema viteae product ES-62 prevents development of collagen-induced arthritis.Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasomeDNA sequence recognition by an isopropyl substituted thiazole polyamide.DNA Minor Groove Binders-Inspired by Nature.Antimicrobial lexitropsins containing amide, amidine, and alkene linking groups.Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity.Selective anti-malarial minor groove binders.An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics.Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy.Four pyrrole derivatives used as building blocks in the synthesis of minor-groove binders.2,2,2-Trifluoro-N-(isoquinolin-5-ylmeth-yl)acetamide.Crystal structure of N,N-dimethyl-2-[(4-methyl-benz-yl)sulfon-yl]ethanamine.Thiazotropsin aggregation and its relationship to molecular recognition in the DNA minor groove.Short lexitropsin that recognizes the DNA minor groove at 5'-ACTAGT-3': understanding the role of isopropyl-thiazole.Synthesis and antimicrobial activity of some netropsin analogues.M4 agonists/5HT7 antagonists with potential as antischizophrenic drugs: serominic compounds.A method for the analysis of sugars in biological systems using reductive amination in combination with hydrophilic interaction chromatography and high resolution mass spectrometry.DNA binding of a short lexitropsin.Amide isosteres in structure-activity studies of antibacterial minor groove bindersA detailed binding free energy study of 2 : 1 ligand–DNA complex formation by experiment and simulationA new synthesis of alkene-containing minor-groove binders and essential hydrogen bonding in binding to DNA and in antibacterial activityDNA sequence recognition by an imidazole-containing isopropyl-substituted thiazole polyamide (thiazotropsin B)Unexpected Dealkylation During Nucleophilic Substitution: Synthesis of 2-N,N-Dialkylamino Benzoxazoles and Benzothiazoles3-Acetoxycyclohex-4-ene-1,2-dicarboxylic anhydrideOn the Specificity of Reactions Catalysed by the Antibody H11Synthesis of novel DNA binding agents: indole-containing analogues of bis-netropsinSynthetic analogues of the parasitic worm product ES-62 reduce disease development in in vivo models of lung fibrosisNovel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model
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P50
description
onderzoeker
@nl
researcher
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հետազոտող
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name
Abedawn I. Khalaf
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Abedawn I. Khalaf
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Abedawn I. Khalaf
@es
Abedawn I. Khalaf
@nl
type
label
Abedawn I. Khalaf
@ast
Abedawn I. Khalaf
@en
Abedawn I. Khalaf
@es
Abedawn I. Khalaf
@nl
altLabel
Abedawn Ibrahim Khalaf
@en
prefLabel
Abedawn I. Khalaf
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Abedawn I. Khalaf
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Abedawn I. Khalaf
@es
Abedawn I. Khalaf
@nl
P106
P1153
7006799960
P31
P4012
P496
0000-0001-9162-7527