Lipid nanoparticle delivery of glucagon receptor siRNA improves glucose homeostasis in mouse models of diabetes

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Lipid nanoparticle delivery of glucagon receptor siRNA improves glucose homeostasis in mouse models of diabetes

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2017 nî lūn-bûn

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Lipid nanoparticle delivery of ...... is in mouse models of diabetes

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Lipid nanoparticle delivery of ...... is in mouse models of diabetes

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Lipid nanoparticle delivery of ...... is in mouse models of diabetes

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Lipid nanoparticle delivery of ...... is in mouse models of diabetes

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Lipid nanoparticle delivery of ...... is in mouse models of diabetes

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Lipid nanoparticle delivery of ...... is in mouse models of diabetes

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Lipid nanoparticle delivery of ...... is in mouse models of diabetes

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Jessica S S Ho

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Pieter R Cullis

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Sam Chen

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Ursula H Neumann

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Yuen Yi C Tam

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P2860

Leptin therapy in insulin-deficient type I diabetes

Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies

Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice

The role of autonomic efferents and uncoupling protein 1 in the glucose-lowering effect of leptin therapy

Glucagon receptor gene deletion in insulin knockout mice modestly reduces blood glucose and ketones but does not promote survival

Leptin activates a novel CNS mechanism for insulin-independent normalization of severe diabetic hyperglycemia.

Leptin deficiency causes insulin resistance induced by uncontrolled diabetes.

Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice

Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance.

Modeling type 2 diabetes in rats using high fat diet and streptozotocin.

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1161-1172

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scholarly article

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10.1016/J.MOLMET.2017.06.012

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Timothy J Kieffer

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2017-06-22T00:00:00Z

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29031717

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nanoparticle

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5641600

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