about
The medicinal chemistry of imidazotetrazine prodrugsDrug binding to DNA x RNA hybrid structuresSynthesis and quantitative structure-activity relationship of imidazotetrazine prodrugs with activity independent of O6-methylguanine-DNA-methyltransferase, DNA mismatch repair, and p53.Glioblastoma multiforme therapy and mechanisms of resistance.Stabilization of a Bimolecular Triplex by 3'-S-Phosphorothiolate Modifications: An NMR and UV Thermal Melting Investigation.Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth.Strategy for Imidazotetrazine Prodrugs with Anticancer Activity Independent of MGMT and MMR.Targeting of tumor cells and DNA by a chlorambucil-spermidine conjugate.Probing the molecular recognition of a DNA.RNA hybrid duplex.Antitumor imidazotetrazines. 32. Synthesis of novel imidazotetrazinones and related bicyclic heterocycles to probe the mode of action of the antitumor drug temozolomide.Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase.In-vitro cytotoxic activities of the major bromophenols of the red alga Polysiphonia lanosa and some novel synthetic isomers.Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands.Polar, functionalized guanine-O6 derivatives resistant to repair by O6-alkylguanine-DNA alkyltransferase: implications for the design of DNA-modifying drugs.Metabolism of cryptolepine and 2-fluorocryptolepine by aldehyde oxidase.Minor structural modifications to alchemix influence mechanism of action and pharmacological activity.Synthesis and growth-inhibitory activities of imidazo[5,1-]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-positionInhibition of cobalamin-dependent methionine synthase by substituted benzo-fused heterocyclesStructural studies on bioactive compounds. Part 27. Chemistry of the immunomodulatory agent bropirimineTelomere-interactive agents affect proliferation rates and induce chromosomal destabilization in sea urchin embryosBiarylpyrimidines: a new class of ligand for high-order DNA recognitionEffects of cationic porphyrins as G-quadruplex interactive agents in human tumor cellsDesign, synthesis, and evaluation of novel biarylpyrimidines: a new class of ligand for unusual nucleic acid structuresRuthenium-Containing Linear Helicates and Mesocates with Tuneable p53-Selective Cytotoxicity in Colorectal Cancer Cells
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P50
description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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name
Richard T. Wheelhouse
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Richard T. Wheelhouse
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Richard T. Wheelhouse
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Richard T. Wheelhouse
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Richard T. Wheelhouse
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type
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Richard T. Wheelhouse
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Richard T. Wheelhouse
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Richard T. Wheelhouse
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Richard T. Wheelhouse
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Richard T. Wheelhouse
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Richard T. Wheelhouse
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Richard T. Wheelhouse
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Richard T. Wheelhouse
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Richard T. Wheelhouse
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Richard T. Wheelhouse
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P108
P1053
B-2519-2009
P106
P1153
6701835591
P21
P31
P3829
P496
0000-0002-2250-3384