about
The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cellsTCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cellsA rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults.Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variantsInsulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention.Incretin-modulated beta cell energetics in intact islets of Langerhans.LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo.Imaging dynamic insulin release using a fluorescent zinc indicator for monitoring induced exocytotic release (ZIMIR).Metabolic regulation of the pancreatic beta-cell ATP-sensitive K+ channel: a pas de deux.GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.Frequency-dependent mitochondrial Ca(2+) accumulation regulates ATP synthesis in pancreatic β cells.Angular Approach Scanning Ion Conductance Microscopy.Increased Expression of the Diabetes Gene SOX4 Reduces Insulin Secretion by Impaired Fusion Pore ExpansionRole of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes.Regulation of ATP production by mitochondrial Ca(2+).Use of genetically encoded sensors to monitor cytosolic ATP/ADP ratio in living cells.A Kir6.2 mutation causing neonatal diabetes impairs electrical activity and insulin secretion from INS-1 beta-cells.Scavenging of 14-3-3 proteins reveals their involvement in the cell-surface transport of ATP-sensitive K+ channels.Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive DiabetesIdentification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis.Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane.Mapping the architecture of the ATP-binding site of the KATP channel subunit Kir6.2.The osmotic characteristics of human fetal liver-derived hematopoietic stem cell candidates.Sulfonylurea improves CNS function in a case of intermediate DEND syndrome caused by a mutation in KCNJ11.Functional analysis of two Kir6.2 (KCNJ11) mutations, K170T and E322K, causing neonatal diabetes.α-cell glucokinase suppresses glucose-regulated glucagon secretion.AP2? Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity.Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization from Acidic Stores in Pancreatic α-Cells.Dramatis Personae in β-Cell Mass Regulation: Enter SerpinB1.Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretionDysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP ProductionElectrophysiological properties of human β-cell lines EndoC-βH1 and -βH2 conform with human β-cellsATP sensitivity of the ATP-sensitive K+ channel in intact and permeabilized pancreatic beta-cellsMonitoring real-time hormone release kinetics via high-content 3-D imaging of compensatory endocytosisImaging Calcium Dynamics in Subpopulations of Mouse Pancreatic Islet CellsGlucose stimulates somatostatin secretion in pancreatic δ-cells by cAMP-dependent intracellular Ca2+ releaseDiabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Andrei I Tarasov
@ast
Andrei I Tarasov
@en
Andrei I Tarasov
@es
Andrei I Tarasov
@nl
type
label
Andrei I Tarasov
@ast
Andrei I Tarasov
@en
Andrei I Tarasov
@es
Andrei I Tarasov
@nl
prefLabel
Andrei I Tarasov
@ast
Andrei I Tarasov
@en
Andrei I Tarasov
@es
Andrei I Tarasov
@nl
P1053
I-6210-2012
P106
P21
P31
P3829
P496
0000-0002-8883-176X