Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound.
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Exploring Internal Ribosome Entry Sites as Therapeutic TargetsThe unfolded protein response in neurodegenerative diseases: a neuropathological perspectiveCrystal structure of eukaryotic translation initiation factor 2BDrosophila as an In Vivo Model for Human Neurodegenerative DiseaseRepurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice.Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APPSwe Mouse Models of Tauopathy and Amyloidosis.Insights into the mechanisms of eukaryotic translation gained with ribosome profilingPharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells.Integrated stress response is critical for gemcitabine resistance in pancreatic ductal adenocarcinomaAn inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response.Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine.The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress.Real-Time Imaging of Translation on Single mRNA Transcripts in Live CellsQualitative Analysis of Emotions: Fear and Thrill.eIF2α-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons.Protein misfolding in the endoplasmic reticulum as a conduit to human disease.A small molecule targeting protein translation does not rescue spatial learning and memory deficits in the hAPP-J20 mouse model of Alzheimer's disease.Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Upstream Open Reading Frames Differentially Regulate Gene-specific Translation in the Integrated Stress ResponseMolecular Determinants of the Regulation of Development and Metabolism by Neuronal eIF2α Phosphorylation in Caenorhabditis elegans.Crystal structure of eIF2B and insights into eIF2-eIF2B interactions.Endoplasmic reticulum proteostasis: a key checkpoint in cancer.Fine-tuning PERK signaling for neuroprotection.eIF2β is critical for eIF5-mediated GDP-dissociation inhibitor activity and translational control.Mitochondrial dysfunction induces SESN2 gene expression through Activating Transcription Factor 4.Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA.Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injuryEndoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells.Translation from the 5' untranslated region shapes the integrated stress responsePPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz.Presynaptic Protein Synthesis Is Required for Long-Term Plasticity of GABA Release.PKR involvement in Alzheimer's diseaseEmerging roles of ER stress in the etiology and pathogenesis of Alzheimer's disease.Elucidating drug targets and mechanisms of action by genetic screens in mammalian cells.Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response.Antagonism of the protein kinase R pathway in human cells by rhesus cytomegalovirus.What Is Our Current Understanding of PrPSc-Associated Neurotoxicity and Its Molecular Underpinnings?Transcriptional correlates of memory maintenance following long-term sensitization of Aplysia californica.CRISPR Approaches to Small Molecule Target Identification.
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P2860
Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Stress responses. Mutations in ...... f a memory-enhancing compound.
@en
Stress responses. Mutations in ...... f a memory-enhancing compound.
@nl
type
label
Stress responses. Mutations in ...... f a memory-enhancing compound.
@en
Stress responses. Mutations in ...... f a memory-enhancing compound.
@nl
prefLabel
Stress responses. Mutations in ...... f a memory-enhancing compound.
@en
Stress responses. Mutations in ...... f a memory-enhancing compound.
@nl
P2860
P50
P356
P1433
P1476
Stress responses. Mutations in ...... f a memory-enhancing compound.
@en
P2093
Alisa Zyryanova
Ana Crespillo-Casado
P2860
P304
P356
10.1126/SCIENCE.AAA6986
P407
P577
2015-04-09T00:00:00Z