What are pharmacological chaperones and why are they interesting?
about
Structural and mechanistic basis of the interaction between a pharmacological chaperone and human phenylalanine hydroxylaseThe use of pharmacological retromer chaperones in Alzheimer's disease and other endosomal-related disorders.Pharmacological chaperones stabilize retromer to limit APP processing.Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson disease-associated α-synuclein.Pharmacological chaperones in the age of proteomic pathology.Phenylalanine hydroxylase misfolding and pharmacological chaperones.DNA binding restricts the intrinsic conformational flexibility of methyl CpG binding protein 2 (MeCP2).Identification and characterization of pharmacological chaperones to correct enzyme deficiencies in lysosomal storage disorders.Structurally distinct ligands rescue biogenesis defects of the KATP channel complex via a converging mechanism.Structural basis for mutation-induced destabilization of profilin 1 in ALS.Saccharomyces cerevisiae Apn1 mutation affecting stable protein expression mimics catalytic activity impairment: implications for assessing DNA repair capacity in humansOn the design of broad based screening assays to identify potential pharmacological chaperones of protein misfolding diseasesCarbamazepine as a novel small molecule corrector of trafficking-impaired ATP-sensitive potassium channels identified in congenital hyperinsulinism.Emerging therapies for neurodegenerative lysosomal storage disorders - from concept to reality.Molecular chaperones as therapeutic targets to counteract proteostasis defects.The multivalent effect in glycosidase inhibition: a new, rapidly emerging topic in glycoscience.Pharmaceutical Chaperones and Proteostasis Regulators in the Therapy of Lysosomal Storage Disorders: Current Perspective and Future Promises.Chaperones as potential therapeutics for Krabbe disease.Bicyclic derivatives of L-idonojirimycin as pharmacological chaperones for neuronopathic forms of Gaucher disease.Screening methods for identifying pharmacological chaperones.Protein misfolding diseases: prospects of pharmacological treatment.Inhibitor mediated protein degradation.Probing structurally altered and aggregated states of therapeutically relevant proteins using GroEL coupled to bio-layer interferometryA systematic investigation of iminosugar click clusters as pharmacological chaperones for the treatment of Gaucher disease.Pharmacoperones for Misfolded Gonadotropin Receptors.An αB-Crystallin Peptide Rescues Compartmentalization and Trafficking Response to Cu Overload of ATP7B-H1069Q, the Most Frequent Cause of Wilson Disease in the Caucasian Population
P2860
Q27678855-D8210567-7C1A-47E9-A1BC-20B8051A5BF5Q30874208-DAC98099-5D74-4298-9846-4AE430C26E4BQ33824953-7DAF8456-EF25-493A-8AD8-2688228F513EQ34002451-97B668C8-68FA-46FE-95BC-21467A2083CCQ34120121-2A912BD6-3DB9-474D-9639-3AF233F47581Q34556955-80ACE401-9B17-4447-B6E8-A394DA306BDCQ34998222-44DA2821-F484-4401-B1F1-AB92F08C7CA4Q35007910-D9E30E5E-2B07-4651-B8CF-2136195074ACQ35199497-824B2CB3-734E-42AE-9129-DF47EA797B27Q35818814-54E1E62D-0468-44AE-B962-964168B24EEBQ36610269-0246C347-81FA-46E7-96F2-88ADF391DED2Q37116655-442D2407-545C-4177-951F-FB6D121657DBQ37175099-24CD998C-0BFF-497D-82C3-39DEF74A5E53Q37876354-ECFC4334-CF8A-481D-B05E-E0EAF2F7A0E1Q37880729-D6213471-C77C-46BC-ADDE-3475DF7DE4B9Q38210134-DE5D919E-EE91-4060-AEB8-0FF48582937CQ38652950-40EA1D31-E6B2-44BF-95D6-90F96F0DE3F2Q38957269-5C561754-295D-4901-B72E-9F121D3D0CE2Q39162679-C0C7D9B6-40CE-4990-B2FC-095CA9AAD438Q39164833-EDA4AB18-0F24-447E-98C9-7F9694E8D20DQ39410882-A0CD617B-B3D1-4460-ABF6-4679DF8DBE56Q42178606-16EA0902-B762-4741-98C1-96158CB79B44Q42553159-0BAC8CFC-4958-4F6A-BE65-9F95D6ABBBF8Q45716125-794A0898-5224-4758-B767-C42B893EA0BAQ47635965-A8EDE979-B64B-4965-8882-9EAE9948ADDDQ57116551-E7A6CCCB-69B2-4A6D-A8FA-5C9B9FA102FD
P2860
What are pharmacological chaperones and why are they interesting?
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
What are pharmacological chaperones and why are they interesting?
@en
What are pharmacological chaperones and why are they interesting?
@nl
type
label
What are pharmacological chaperones and why are they interesting?
@en
What are pharmacological chaperones and why are they interesting?
@nl
prefLabel
What are pharmacological chaperones and why are they interesting?
@en
What are pharmacological chaperones and why are they interesting?
@nl
P2860
P356
P1433
P1476
What are pharmacological chaperones and why are they interesting?
@en
P2860
P2888
P356
10.1186/JBIOL186
P577
2009-10-13T00:00:00Z
P5875
P6179
1001977080