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The KCNQ1 channel - remarkable flexibility in gating allows for functional versatilityKCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two stepsElectrostatic tuning of cellular excitability.Dampening of hyperexcitability in CA1 pyramidal neurons by polyunsaturated fatty acids acting on voltage-gated ion channelsThe free energy barrier for arginine gating charge translation is altered by mutations in the voltage sensor domain.Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac IKs channelElectronic polymers in lipid membranes.Tracking a complete voltage-sensor cycle with metal-ion bridges.The conserved phenylalanine in the K+ channel voltage-sensor domain creates a barrier with unidirectional effects.Reciprocal voltage sensor-to-pore coupling leads to potassium channel C-type inactivation.Structure, function, and modification of the voltage sensor in voltage-gated ion channels.Drug-induced ion channel opening tuned by the voltage sensor charge profile.Fatty acid analogue N-arachidonoyl taurine restores function of IKs channels with diverse long QT mutations.Intracellular K+ concentration decrease is not obligatory for apoptosis.An electrostatic potassium channel opener targeting the final voltage sensor transition.Polyunsaturated fatty acids are potent openers of human M-channels expressed in Xenopus laevis oocytes.Lipoelectric modification of ion channel voltage gating by polyunsaturated fatty acids.Polyunsaturated fatty acids and cerebrospinal fluid from children on the ketogenic diet open a voltage-gated K channel: a putative mechanism of antiseizure action.KCNE1 tunes the sensitivity of K7.1 to polyunsaturated fatty acids by moving turret residues close to the binding siteMechanisms Underlying the Dual Effect of Polyunsaturated Fatty Acid Analogs on Kv7.1An intracellular glucose biosensor based on nanoflake ZnOω-6 and ω-9 polyunsaturated fatty acids with double bonds near the carboxyl head have the highest affinity and largest effects on the cardiac IK s potassium channel.Polyunsaturated fatty acid analogues differentially affect cardiac Nav, Cav, and Kv channels through unique mechanismsPolyunsaturated fatty acid-derived IKs channel activators shorten the QT interval ex-vivo and in-vivoCorrection: Polyunsaturated fatty acid analogues differentially affect cardiac NaV, CaV, and KV channels through unique mechanisms
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description
Zweeds onderzoekster
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Sara I Börjesson
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Sara Börjesson
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Sara I Börjesson
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P214
P906
P106
P2038
P21
P214
P27
P31
P496
0000-0001-8493-0114
P569
1982-01-01T00:00:00Z
P734
P735
P7859
viaf-170136841