about
2-Hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs), novel inhibitors of HIV integrase with a high barrier to resistanceValidation and structural characterization of the LEDGF/p75-MLL interface as a new target for the treatment of MLL-dependent leukemiaMultiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motifTracing the origin of disseminated tumor cells in breast cancer using single-cell sequencingA symmetric region of the HIV-1 integrase dimerization interface is essential for viral replicationHIV virions as nanoscopic test tubes for probing oligomerization of the integrase enzyme.4-Substituted 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as a Novel Class of HIV-1 Integrase InhibitorsIdentification of a small molecule that modulates platelet glycoprotein Ib-von Willebrand factor interactionThe HIV-1 integrase mutant R263A/K264A is 2-fold defective for TRN-SR2 binding and viral nuclear import.LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINsThe BET family of proteins targets moloney murine leukemia virus integration near transcription start sites.HIV-1 IN/Pol recruits LEDGF/p75 into viral particlesTowards a Safer, More Randomized Lentiviral Vector Integration Profile Exploring Artificial LEDGF Chimeras.Rational design of LEDGINs as first allosteric integrase inhibitors for the treatment of HIV infection.LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014).HIV-1 integrase variants retarget viral integration and are associated with disease progression in a chronic infection cohort.BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements.Cellular cofactors of lentiviral integrase: from target validation to drug discovery.Interaction of transportin-SR2 with Ras-related nuclear protein (Ran) GTPaseDiscovery of small molecule HIV-1 integrase dimerization inhibitors.Impairing MLL-fusion gene-mediated transformation by dissecting critical interactions with the lens epithelium-derived growth factor (LEDGF/p75).Development of an AlphaScreen-based HIV-1 integrase dimerization assay for discovery of novel allosteric inhibitors.LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis.Characterization of rare lens epithelium-derived growth factor/p75 genetic variants identified in HIV-1 long-term nonprogressors.Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors.Inhibitors of the integrase-transportin-SR2 interaction block HIV nuclear import.Bromodomain and extra-terminal (BET) proteins target Moloney murine leukemia virus integration to transcription start sites.Recurrent rearrangements of FOS and FOSB define osteoblastoma.The evolutionary history of 2,658 cancersStructure, mechanics, and binding mode heterogeneity of LEDGF/p75–DNA nucleoprotein complexes revealed by scanning force microscopyAffinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylationPan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotranspositionNeoantigen-directed immune escape in lung cancer evolution
P50
Q27684221-E1870EDD-DB49-46DC-855C-0DF138D29FA8Q27694683-FBE5D7CC-0700-44E0-B97D-96173875E1DBQ27701733-6B082847-45B5-45D6-8EB7-7F92C3935619Q28396153-89070B9D-47EC-411D-8A73-816B2E0A7312Q28483813-914F995C-0624-4372-A64C-9CB9DD938FBEQ30407372-9EA46B46-A241-4F2D-8A4B-14F8467A7979Q33636046-FEBED9B3-4BB7-4690-A89D-8596CE2860AFQ34122627-E7999FCD-239E-4561-9B30-2950BD2FE691Q34139212-448797E2-A303-47C5-92E5-99E10AA653F9Q34186964-5D5F6066-1508-4D28-B8D1-390F897B29C3Q34342339-7AC7FF2D-0F3E-46F0-B861-D25597D61744Q35170009-144CDA3B-3E06-4A44-9687-1A78039659A4Q36176014-AAA417FA-397B-444D-8C6F-991FCD7D6CC4Q38180878-33093186-535E-4B7B-A92E-E7D399C1D6B7Q38199193-5E1C4FDE-89A4-4869-BA13-B6489BB35F40Q41590414-BDAF0546-AE19-4764-816B-2AC7C903E7AFQ42203159-B30E0558-32FD-48E0-B40D-B3953F2E1874Q42277905-3013EC15-0533-4919-9F6E-BA76E470D2B3Q42282078-8ED6F674-7964-4448-9FFC-0CF7BA8A9A7CQ42719255-EF944DB1-5154-4F20-AAF8-7EA065B56A57Q44738170-3068A77A-FDCB-449E-B9E8-67BD245147E6Q45157847-E3FB5A69-83CD-4FE5-A12B-6D4D9499B8D2Q45873757-59705AA2-E8ED-414E-A9AC-B60DC7178195Q45883578-985A517F-17D8-45C2-BCA4-BCA892C77CDEQ45988269-9ACA5841-16D0-4C52-94B1-F362712B7F1CQ47554259-00FCC1A9-986D-4288-A5B2-E4F5FE81CBFCQ50327371-F05FF1A7-A717-46E0-8F3E-DC997B153C88Q54982091-7AD14BF8-3F7D-4252-90E4-D3ADC94BB2BAQ57783527-D85A5502-3DF8-4C59-9655-3D8BF61DF3E6Q57937336-44487CB2-86EB-41A0-84FB-9366555C8871Q59357156-60B225FF-DD56-469B-9B4C-61526F419F59Q89556828-00A790BB-8EB0-4804-93FC-3771506468A5Q92512819-0CE713E7-FE3E-4216-A0C5-F1F37C32316A
P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Jonas Demeulemeester
@ast
Jonas Demeulemeester
@en
Jonas Demeulemeester
@es
Jonas Demeulemeester
@nl
Jonas Demeulemeester
@sl
type
label
Jonas Demeulemeester
@ast
Jonas Demeulemeester
@en
Jonas Demeulemeester
@es
Jonas Demeulemeester
@nl
Jonas Demeulemeester
@sl
prefLabel
Jonas Demeulemeester
@ast
Jonas Demeulemeester
@en
Jonas Demeulemeester
@es
Jonas Demeulemeester
@nl
Jonas Demeulemeester
@sl
P1053
J-6130-2014
P106
P21
P31
P3829
P496
0000-0002-2660-2478