Biosynthesis of galactofuranose in kinetoplastids: novel therapeutic targets for treating leishmaniasis and chagas' disease. - Test2 - elhamkhani - TriplyDB

Biosynthesis of galactofuranose in kinetoplastids: novel therapeutic targets for treating leishmaniasis and chagas' disease.

Biosynthesis of galactofuranose in kinetoplastids: novel therapeutic targets for treating leishmaniasis and chagas' disease.

http://www.wikidata.org/entity/Q42752718

about

Predicting the proteins of Angomonas deanei, Strigomonas culicis and their respective endosymbionts reveals new aspects of the trypanosomatidae family The genome of the heartworm, Dirofilaria immitis, reveals drug and vaccine targets Targeting UDP-galactopyranose mutases from eukaryotic human pathogens Crystal Structures of Trypanosoma cruzi UDP-Galactopyranose Mutase Implicate Flexibility of the Histidine Loop in Enzyme Activation Chemical mechanism of UDP-galactopyranose mutase from Trypanosoma cruzi: a potential drug target against Chagas' disease Alkyl galactofuranosides strongly interact with Leishmania donovani membrane and provide antileishmanial activity Study of Uridine 5'-Diphosphate (UDP)-Galactopyranose Mutase Using UDP-5-Fluorogalactopyranose as a Probe: Incubation Results and Mechanistic Implications.Stage-specific differential gene expression in Leishmania infantum: from the foregut of Phlebotomus perniciosus to the human phagocyte.In silico work flow for scaffold hopping in Leishmania Contributions of unique active site residues of eukaryotic UDP-galactopyranose mutases to substrate recognition and active site dynamics.QM/MM molecular dynamics study of the galactopyranose → galactofuranose reaction catalysed by Trypanosoma cruzi UDP-galactopyranose mutase.Noncanonical reactions of flavoenzymes.Unusual galactofuranose modification of a capsule polysaccharide in the pathogenic yeast Cryptococcus neoformans.Structure, mechanism, and dynamics of UDP-galactopyranose mutase.Deciphering the sugar biosynthetic pathway and tailoring steps of nucleoside antibiotic A201A unveils a GDP-l-galactose mutase.Mannoside recognition and degradation by bacteria.UDP-galactopyranose mutase, a potential drug target against human pathogenic nematode Brugia malayi.The efficacy of L. (L.) chagasi excreted-secreted antigens (ESAs) for visceral leishmaniasis diagnosis is due to low levels of cross-reactivity.Multiple functionalities of reduced flavin in the non-redox reaction catalyzed by UDP-galactopyranose mutase.Identification of novel inhibitors against UDP-galactopyranose mutase to combat leishmaniasis.

P2860

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P2860

Biosynthesis of galactofuranose in kinetoplastids: novel therapeutic targets for treating leishmaniasis and chagas' disease.

http://www.wikidata.org/entity/Q42752718

description

2011 nî lūn-bûn

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

Biosynthesis of galactofuranos ...... hmaniasis and chagas' disease.

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Biosynthesis of galactofuranos ...... hmaniasis and chagas' disease.

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Biosynthesis of galactofuranos ...... hmaniasis and chagas' disease.

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Biosynthesis of galactofuranos ...... hmaniasis and chagas' disease.

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Biosynthesis of galactofuranos ...... hmaniasis and chagas' disease.

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Biosynthesis of galactofuranos ...... hmaniasis and chagas' disease.

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Enzyme research

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Biosynthesis of galactofuranos ...... hmaniasis and chagas' disease.

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Ana L Valenciano

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Michelle Oppenheimer

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Pablo Sobrado

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P2860

The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease

UDP-galactopyranose mutase has a novel structure and mechanism

High-resolution crystal structure of Trypanosoma brucei UDP-galactose 4'-epimerase: a potential target for structure-based development of novel trypanocides

X-ray crystallography reveals a reduced substrate complex of UDP-galactopyranose mutase poised for covalent catalysis by flavin

Structural basis of substrate binding to UDP-galactopyranose mutase: crystal structures in the reduced and oxidized state complexed with UDP-galactopyranose and UDP

Structural basis for the broad substrate range of the UDP-sugar pyrophosphorylase from Leishmania major

ESPript: analysis of multiple sequence alignments in PostScript

Reactivity of MEST-1 (antigalactofuranose) with Trypanosoma cruzi glycosylinositol phosphorylceramides (GIPCs): immunolocalization of GIPCs in acidic vesicles of epimastigotes

Lytic anti-alpha-galactosyl antibodies from patients with chronic Chagas' disease recognize novel O-linked oligosaccharides on mucin-like glycosyl-phosphatidylinositol-anchored glycoproteins of Trypanosoma cruzi

Biosynthetic origin of mycobacterial cell wall galactofuranosyl residues

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10.4061/2011/415976

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2011

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