A natural killer cell granule protein that induces DNA fragmentation and apoptosis.
about
Granzyme B inhibits vaccinia virus production through proteolytic cleavage of eukaryotic initiation factor 4 gamma 3Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicksHMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme ACathepsin H is an additional convertase of pro-granzyme BA cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytesIdentification and functional characterization of a TIA-1-related nucleolysinCleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme AThe continuing challenges of leprosyDirect cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentationA quarter century of granzymesPurification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactionsThe Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32Granzyme K activates protease-activated receptor-1Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis.Induction of rapid histone degradation by the cytotoxic T lymphocyte protease Granzyme A.Anti-viral strategies of cytotoxic T lymphocytes are manifested through a variety of granule-bound pathways of apoptosis induction.Functional CD32 molecules on human NK cells.Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathwayThe human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes.Apoptosis and predisposition to oral cancer.Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin.Granzyme A activates another way to dieIdentification of human granzyme B promoter regulatory elements interacting with activated T-cell-specific proteins: implication of Ikaros and CBF binding sites in promoter activation.Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.Mutational analysis of the Caenorhabditis elegans cell-death gene ced-3.Targeted apoptosis activation with GrB/scFvMEL modulates melanoma growth, metastatic spread, chemosensitivity, and radiosensitivity.Granzyme B: a natural born killer.Postexposure treatment with the live-attenuated rabies virus (RV) vaccine TriGAS triggers the clearance of wild-type RV from the Central Nervous System (CNS) through the rapid induction of genes relevant to adaptive immunity in CNS tissues.Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis.The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.Perforin and lymphohistiocytic proliferative disorders.Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosisA clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death.Protease inhibitors selectively block T cell receptor-triggered programmed cell death in a murine T cell hybridoma and activated peripheral T cellsSeparate metabolic pathways leading to DNA fragmentation and apoptotic chromatin condensationRescue from granzyme B-induced apoptosis by Wee1 kinase.Interleukin-1 beta-converting enzyme-like protease cleaves DNA-dependent protein kinase in cytotoxic T cell killing.Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization.Activation of CPP32-like proteases is not sufficient to trigger apoptosis: inhibition of apoptosis by agents that suppress activation of AP24, but not CPP32-like activity.
P2860
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P2860
A natural killer cell granule protein that induces DNA fragmentation and apoptosis.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
A natural killer cell granule protein that induces DNA fragmentation and apoptosis.
@en
A natural killer cell granule protein that induces DNA fragmentation and apoptosis.
@nl
type
label
A natural killer cell granule protein that induces DNA fragmentation and apoptosis.
@en
A natural killer cell granule protein that induces DNA fragmentation and apoptosis.
@nl
prefLabel
A natural killer cell granule protein that induces DNA fragmentation and apoptosis.
@en
A natural killer cell granule protein that induces DNA fragmentation and apoptosis.
@nl
P2093
P2860
P356
P1476
A natural killer cell granule protein that induces DNA fragmentation and apoptosis.
@en
P2093
P2860
P304
P356
10.1084/JEM.175.2.553
P407
P577
1992-02-01T00:00:00Z