Ubiquitylation of the amino terminus of Myc by SCF(β-TrCP) antagonizes SCF(Fbw7)-mediated turnover.
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ABC transporter functions as a pacemaker for sequestration of plant glucosides in leaf beetlesThe ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stabilityDomain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activityCompeting E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasmMEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancerUbiquitin on the move: the ubiquitin modification system plays diverse roles in the regulation of endoplasmic reticulum- and plasma membrane-localized proteinsRoles of protein ubiquitination and degradation kinetics in biological oscillationsMYC on the path to cancerCUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1Protein kinase A regulates MYC protein through transcriptional and post-translational mechanisms in a catalytic subunit isoform-specific manner.A design principle underlying the paradoxical roles of E3 ubiquitin ligasesThe role of the human psoralen 4 (hPso4) protein complex in replication stress and homologous recombination.RNAi screen identifies a synthetic lethal interaction between PIM1 overexpression and PLK1 inhibitionMYC cofactors: molecular switches controlling diverse biological outcomes.Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3.Stabilization of Myc through heterotypic poly-ubiquitination by mLANA is critical for γ-herpesvirus lymphoproliferation.β-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells.Nitric oxide increases lysine 48-linked ubiquitination following arterial injury.The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-MycBIM is the primary mediator of MYC-induced apoptosis in multiple solid tissues.Regulation of c-Myc protein stability by proteasome activator REGγThe opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis.Competition between Decapping Complex Formation and Ubiquitin-Mediated Proteasomal Degradation Controls Human Dcp2 Decapping Activity.DNA Damage Regulates Translation through β-TRCP Targeting of CRePTelomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity.ELL targets c-Myc for proteasomal degradation and suppresses tumour growth.E3 Ubiquitin Ligase RLIM Negatively Regulates c-Myc Transcriptional Activity and Restrains Cell ProliferationProtein turnover during in vitro tissue engineering.Translational and post-translational regulation of mouse cation transport regulator homolog 1CDK-mediated activation of the SCF(FBXO) (28) ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer.MYC degradation under low O2 tension promotes survival by evading hypoxia-induced cell death.The Smad7-Skp2 complex orchestrates Myc stability, impacting on the cytostatic effect of TGF-βSCFs in the new millennium.Oncoprotein stabilization in brain tumors.MYC degradationPost-translational control of Myc function during differentiation.Lysine-52 stabilizes the MYC oncoprotein through an SCF(Fbxw7)-independent mechanism.Dose-dependent regulation of target gene expression and cell proliferation by c-Myc levels.Deubiquitinating c-Myc: USP36 steps up in the nucleolus.The ubiquitin-proteasome system and chromosome 17 in cerebellar granule cells and medulloblastoma subgroups.
P2860
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P2860
Ubiquitylation of the amino terminus of Myc by SCF(β-TrCP) antagonizes SCF(Fbw7)-mediated turnover.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Ubiquitylation of the amino terminus of Myc by SCF
@nl
Ubiquitylation of the amino te ...... s SCF(Fbw7)-mediated turnover.
@en
type
label
Ubiquitylation of the amino terminus of Myc by SCF
@nl
Ubiquitylation of the amino te ...... s SCF(Fbw7)-mediated turnover.
@en
prefLabel
Ubiquitylation of the amino terminus of Myc by SCF
@nl
Ubiquitylation of the amino te ...... s SCF(Fbw7)-mediated turnover.
@en
P2093
P356
P1433
P1476
Ubiquitylation of the amino te ...... s SCF(Fbw7)-mediated turnover.
@en
P2093
Christina Schülein
Laura A Jaenicke
Nikita Popov
P2860
P2888
P304
P356
10.1038/NCB2104
P577
2010-09-19T00:00:00Z