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Hypothalamic/pituitary-axis of the spontaneous dwarf rat: autofeedback regulation of growth hormone (GH) includes suppression of GH releasing-hormone receptor messenger ribonucleic acidEffects of antagonists of growth hormone-releasing hormone (GHRH) on GH and insulin-like growth factor I levels in transgenic mice overexpressing the human GHRH gene, an animal model of acromegalyRole of glucocorticoids in the regulation of pituitary somatostatin receptor subtype (sst1-sst5) mRNA levels: evidence for direct and somatostatin-mediated effectsImpact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary functionGlucocorticoids regulate pituitary growth hormone secretagogue receptor gene expression.Metabolic impact of adult-onset, isolated, growth hormone deficiency (AOiGHD) due to destruction of pituitary somatotropesTargeted deletion of somatotroph insulin-like growth factor-I signaling in a cell-specific knockout mouse modelA novel human ghrelin variant (In1-ghrelin) and ghrelin-O-acyltransferase are overexpressed in breast cancer: potential pathophysiological relevance.Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).A mutant allele of BARA/LIN-9 rescues the cdk4-/- phenotype by releasing the repression on E2F-regulated genes.The somatotrope as a metabolic sensor: deletion of leptin receptors causes obesity.Growth hormone-releasing hormone and pituitary development, hyperplasia and tumorigenesis.Melatonin regulates somatotrope and lactotrope function through common and distinct signaling pathways in cultured primary pituitary cells from female primatesTruncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomasKisspeptin regulates gonadotroph and somatotroph function in nonhuman primate pituitary via common and distinct signaling mechanismsRole of ghrelin system in neuroprotection and cognitive functions: implications in Alzheimer's disease.Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner.Cortistatin is not a somatostatin analogue but stimulates prolactin release and inhibits GH and ACTH in a gender-dependent fashion: potential role of ghrelin.Homologous and heterologous in vitro regulation of pituitary receptors for somatostatin, growth hormone (GH)-releasing hormone, and ghrelin in a nonhuman primate (Papio anubis).Growth Hormone Inhibits Hepatic De Novo Lipogenesis in Adult MiceDoes the pituitary somatotrope play a primary role in regulating GH output in metabolic extremes?Ablation of leptin signaling to somatotropes: changes in metabolic factors that cause obesityThe rise in growth hormone during starvation does not serve to maintain glucose levels or lean mass but is required for appropriate adipose tissue response in female miceDisruption of growth hormone signaling retards prostate carcinogenesis in the Probasin/TAg ratEndogenous somatostatin is critical in regulating the acute effects of L-arginine on growth hormone and insulin release in mice.Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms.Role of endogenous somatostatin in regulating GH output under basal conditions and in response to metabolic extremes.Use of the metallothionein promoter-human growth hormone-releasing hormone (GHRH) mouse to identify regulatory pathways that suppress pituitary somatotrope hyperplasia and adenoma formation due to GHRH-receptor hyperactivation.Expression analysis of dopamine receptor subtypes in normal human pituitaries, nonfunctioning pituitary adenomas and somatotropinomas, and the association between dopamine and somatostatin receptors with clinical response to octreotide-LAR in acromeBoth estrogen receptor α and β stimulate pituitary GH gene expression.Long- but not short-term adult-onset, isolated GH deficiency in male mice leads to deterioration of β-cell function, which cannot be accounted for by changes in β-cell mass.Obestatin plays an opposite role in the regulation of pituitary somatotrope and corticotrope function in female primates and male/female mice.Effects of leptin replacement on hypothalamic-pituitary growth hormone axis function and circulating ghrelin levels in ob/ob mice.Identification of a mouse ghrelin gene transcript that contains intron 2 and is regulated in the pituitary and hypothalamus in response to metabolic stress.Cdk4 is indispensable for postnatal proliferation of the anterior pituitary.Loss of heterozygosity on chromosome 11q13 in two families with acromegaly/gigantism is independent of mutations of the multiple endocrine neoplasia type I gene.Islet insulin content and release are increased in male mice with elevated endogenous GH and IGF-I, without evidence of systemic insulin resistance or alterations in β-cell mass.Identification of the somatostatin receptor subtypes (sst) mediating the divergent, stimulatory/inhibitory actions of somatostatin on growth hormone secretion.A cellular basis for growth hormone deficiency in the dwarf rat: analysis of growth hormone and prolactin release by reverse hemolytic plaque assay.Dynamic monitoring and quantification of gene expression in single, living cells: a molecular basis for secretory cell heterogeneity.
P50
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P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Rhonda D Kineman
@ast
Rhonda D Kineman
@en
Rhonda D Kineman
@es
Rhonda D Kineman
@nl
Rhonda D Kineman
@sl
type
label
Rhonda D Kineman
@ast
Rhonda D Kineman
@en
Rhonda D Kineman
@es
Rhonda D Kineman
@nl
Rhonda D Kineman
@sl
prefLabel
Rhonda D Kineman
@ast
Rhonda D Kineman
@en
Rhonda D Kineman
@es
Rhonda D Kineman
@nl
Rhonda D Kineman
@sl
P1053
H-2221-2011
P106
P21
P31
P3829
P496
0000-0001-7322-1152
P569
2000-01-01T00:00:00Z