Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4. - Test2 - elhamkhani - TriplyDB

Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.

Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.

http://www.wikidata.org/entity/Q42915550

about

Protease inhibition as new therapeutic strategy for GI diseases Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain.Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs Biased ligand quantification in drug discovery: from theory to high throughput screening to identify new biased μ opioid receptor agonists Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury.TRPV4 as a therapeutic target for joint diseases.Molecular and cellular mechanisms that initiate pain and itch.Protein Kinase D and Gβγ Subunits Mediate Agonist-evoked Translocation of Protease-activated Receptor-2 from the Golgi Apparatus to the Plasma Membrane.Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch.Design of a highly selective quenched activity-based probe and its application in dual color imaging studies of cathepsin S activity localization.ThermoTRPs and Pain.Sensitivity to wheat, gluten and FODMAPs in IBS: facts or fiction?Pathophysiological roles of proteases in gastrointestinal disease.Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Proteinases, Their Extracellular Targets, and Inflammatory Signaling.TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization.Protease-Activated Receptor 2 contributes to Toxoplasma gondii-mediated gut inflammation.Neonatal immune challenge followed by adult immune challenge induces epigenetic-susceptibility to aggravated visceral hypersensitivity.Cathepsin S Is Involved in Th17 Differentiation Through the Upregulation of IL-6 by Activating PAR-2 after Systemic Exposure to Lipopolysaccharide from Porphyromonas gingivalis.Interferon-γ treatment in vitro elicits some of the changes in cathepsin S and antigen presentation characteristic of lacrimal glands and corneas from the NOD mouse model of Sjögren's Syndrome.Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain.Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2.Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR1 signalling.Potent Small Agonists of Protease Activated Receptor 2.Protease-Mediated Suppression of DRG Neuron Excitability by Commensal Bacteria.Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission.Regulation of Pain and Itch by TRP Channels.Granulocyte-colony-stimulating factor (G-CSF) signaling in spinal microglia drives visceral sensitization following colitis.Distinct Gene Profiles of Bone Marrow-Derived Macrophages and Microglia During Neurotropic Coronavirus-Induced Demyelination.Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

P2860

Q26747722-C4BC74A0-37AE-4E2D-82A5-0704A859F2C2 Q27349086-E8002244-ACF5-47E6-95A2-5E1EE8647AE4 Q28265606-DFE66DDD-B14C-4751-AD67-FD63BDA4026A Q30359656-1B8D21D2-8223-4CC4-9CC8-23BFD451B48B Q33765990-211ED9CA-EB19-4561-BA4C-119C74A65E15 Q35181627-21CC937C-0A88-447D-A743-64C1C842F3DC Q35946504-85F05D35-49F9-4C07-AB7D-039461D7602E Q35974569-7FA5E946-F239-47C4-8ADD-8D2C259E3DB1 Q36876222-2DFF5AD7-7AA3-4DAF-9171-E8FEF3ED588B Q38320736-439AF734-A66C-499F-B5FA-4472ADCFB505 Q38327187-D748A318-BA26-48EA-81A8-8A602B192408 Q38409759-92A5E2C4-543E-4846-ACA4-913F5098AFF5 Q38678675-FAFCCBD6-DC87-466A-8DBA-A0E122741BD7 Q38758445-25875B21-519C-4AF1-8869-AA3B4C37B1F4 Q38966192-57401A74-8611-445A-BE61-11F422D2FA9E Q39212353-9E6C7D92-1B8B-4AF4-ACE5-C8CB6C0FB28E Q40062647-F9D06CDE-AA62-412D-BB93-461CE2BCEE32 Q40238937-3AE354D2-5A52-4B93-B96A-517D9123A385 Q41024037-45C51EA8-6F76-47D7-9D98-E055166EF16D Q41140614-623E76D9-951F-4A2E-8C01-D9EE9C09A26F Q41298460-8BC53161-618E-4238-A3D1-EB1BE92410BD Q41341638-9C63CD55-8D0A-425D-A2D1-603DEC99B1B0 Q41635414-1D95D090-6BB7-4F7D-AB2A-21B7DC89E685 Q43083912-EE332099-E681-4333-A563-6F4D20E2EFE8 Q46271336-5258AA99-B691-479E-9261-3B247FAFF6EC Q47583720-DE06A7D8-3A91-4A66-8675-D49F13170C49 Q48339961-3D58876E-2D65-462C-9C06-9973F4F70328 Q49646739-BC183B49-CBC6-48C6-ABCD-8F7F16186EB1 Q55376062-7569C028-F14B-45BE-9598-C744506BDE71 Q60730296-df4acb4f-4366-26d1-db5b-a156cabd23c9

P2860

Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.

http://www.wikidata.org/entity/Q42915550

description

2014 nî lūn-bûn

@nan

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

2014年论文

@zh

2014年论文

@zh-cn

name

Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.

@en

type

label

Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.

@en

prefLabel

Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.

@en

P1433

Q42915550-EE9BD8EC-C715-4922-B767-D9C99DE6435F

P1476

Q42915550-4355A9DA-F77F-494D-A5F1-B6C6F561FAED

P2093

Q42915550-4004F512-69D2-4FC9-A091-311839A5E903

Q42915550-4ECC1AE8-3D19-4B2F-B588-1C619A18248B

Q42915550-6887FD49-2CCC-4DB9-AF06-EDB5174F8232

Q42915550-75675FB2-265F-47B7-88C7-8E5DD102CAB0

Q42915550-77591DEB-2B4B-475C-926D-13AFCAD02C30

Q42915550-7C748B2E-C25D-417F-A73C-4ECFA92061B1

Q42915550-7D8017BF-8E36-4450-9184-90218C96C5FF

Q42915550-8F43A20E-BCC2-4E15-A900-8C5764432F0C

Q42915550-97E2492D-CFDF-4E87-B25C-70DAABD5F2DC

Q42915550-A1CCF252-FBA6-481A-9713-ECE2DFD5C4A7

P2860

Q42915550-0350FDED-173E-4285-826D-3FC27C3D2B40

Q42915550-0BEBEC83-453F-45E5-9AE6-92956B56019B

Q42915550-0D16CEB2-32CC-4454-8BB0-79225AEE86AA

Q42915550-10379CEF-CCAA-452E-A061-2AB63E649536

Q42915550-1BDED252-1FD4-4299-B1C2-A661105A9E2C

Q42915550-1D12E5BF-C18C-4CA8-9376-9601E0A02B89

Q42915550-1E7EC588-3C55-49A1-8561-7206ED70E14E

Q42915550-219BCCEF-BF25-49AA-92D3-B8B3E5375997

Q42915550-2CC7E3DB-DA81-429D-88DB-0E609D6E626C

Q42915550-2DEB09B6-7204-4391-A868-7617B81DBC7A

P304

Q42915550-9385597D-5A8A-4C10-8713-8BEA70FDC16C

P31

Q42915550-2FBCB166-F569-408F-BE8D-A8D9FE1F5F1F

P356

Q42915550-5792DF47-5D32-44EA-82E1-300170024BE5

P407

Q42915550-73248DA6-8A7D-47DB-9244-736B73C77B79

P433

Q42915550-4CD7F1BA-8988-4E6B-89AD-3F7C376F7C55

P478

Q42915550-BFC7E8CB-FAAE-4DF6-A648-F8DB5621B727

P50

Q42915550-158EFBEA-B7C5-4D57-A0D8-7A1D51F1567B

Q42915550-38B7525B-BB5C-47F5-8C22-A6B139256C4F

Q42915550-64DA75E8-DBB6-4A45-83A2-C4C46A42E408

Q42915550-C01D659E-9FA7-471B-9947-6F5617BADBF7

P577

Q42915550-257BB130-239A-41A3-8171-9BA877402D01

P698

Q42915550-5B2F9319-24F7-49CF-ACCE-6559F0B0AFF5

P932

Q42915550-E0264BBD-40D0-4E8B-9C48-522F55F0D92A

P356

JBC.M114.599712

P1433

Journal of Biological Chemistry

P1476

Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.

@en

P2093

Christoph Korbmacher

http://www.w3.org/2001/XMLSchema#string

Dane D Jensen

http://www.w3.org/2001/XMLSchema#string

Eduardo E Valdez-Morales

http://www.w3.org/2001/XMLSchema#string

Erik Lindström

http://www.w3.org/2001/XMLSchema#string

Ian Henderson

http://www.w3.org/2001/XMLSchema#string

Matthew Metcalf

http://www.w3.org/2001/XMLSchema#string

Nigel W Bunnett

http://www.w3.org/2001/XMLSchema#string

Peishen Zhao

http://www.w3.org/2001/XMLSchema#string

Peter McIntyre

http://www.w3.org/2001/XMLSchema#string

Raquel Guerrero-Alba

http://www.w3.org/2001/XMLSchema#string

P2860

Cathepsin S signals via PAR2 and generates a novel tethered ligand receptor agonist

Role for protease activity in visceral pain in irritable bowel syndrome

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates

Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S

Proteinase-activated receptors, targets for kallikrein signaling

Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2

The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells

Molecular cloning of a potential proteinase activated receptor

Inflammatory mediators regulate cathepsin S in macrophages and microglia: A role in attenuating heparan sulfate interactions

P304

27215-27234

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M114.599712

http://www.w3.org/2001/XMLSchema#string

P407

P433

39

http://www.w3.org/2001/XMLSchema#string

P478

289

http://www.w3.org/2001/XMLSchema#string

P50

Nicholas Veldhuis

Nicholas Barlow

P577

2014-08-12T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

25118282

http://www.w3.org/2001/XMLSchema#string

P932

4175355

http://www.w3.org/2001/XMLSchema#string