about
Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domainThe PRH/Hex repressor protein causes nuclear retention of Groucho/TLE co-repressorsDNA wrapping and distortion by an oligomeric homeodomain proteinA functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factorsMisregulation of the proline rich homeodomain (PRH/HHEX) protein in cancer cells and its consequences for tumour growth and invasionComparison of the structure and DNA-binding properties of the E2 proteins from an oncogenic and a non-oncogenic human papillomavirusThe proline rich homeodomain protein PRH/Hhex forms stable oligomers that are highly resistant to denaturationIn situ subcellular fractionation of adherent and non-adherent mammalian cellsPRH/Hhex controls cell survival through coordinate transcriptional regulation of vascular endothelial growth factor signaling.Transcriptional repression in eukaryotes: repressors and repression mechanisms.P53 represses human papillomavirus type 16 DNA replication via the viral E2 proteinA quadrivalent vaccine for human papillomavirus.Purification of the proline-rich homeodomain protein.The Enigmatic Origin of Papillomavirus Protein Domains.Proline-Rich Homeodomain protein (PRH/HHEX) is a suppressor of breast tumour growth.CK2 abrogates the inhibitory effects of PRH/HHEX on prostate cancer cell migration and invasion and acts through PRH to control cell proliferation.PRH/HHex inhibits the migration of breast and prostate epithelial cells through direct transcriptional regulation of Endoglin.Dasatinib inhibits leukaemic cell survival by decreasing PRH/Hhex phosphorylation resulting in increased repression of VEGF signalling genes.The human papillomavirus E7-E2 interaction mechanism in vitro reveals a finely tuned system for modulating available E7 and E2 proteins.Herpes simplex virus VP22-human papillomavirus E2 fusion proteins produced in mammalian or bacterial cells enter mammalian cells and induce apoptotic cell death.DNA compaction by the higher-order assembly of PRH/Hex homeodomain protein oligomers.Novel mechanisms of resistance to vemurafenib in melanoma - V600E B-Raf reversion and switching VEGF-A splice isoform expression.Protein flexibility directs DNA recognition by the papillomavirus E2 proteins.The recognition of local DNA conformation by the human papillomavirus type 6 E2 protein.Human papillomavirus type 16 E2- and L1-specific serological and T-cell responses in women with vulval intraepithelial neoplasia.Diffusible VP22-E2 protein kills bystander cells and offers a route for cervical cancer gene therapy.Purification and characterisation of the PRH homeodomain: Removal of the N-terminal domain of PRH increases the PRH homeodomain-DNA interaction.Protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism.A cancer cell-specific inducer of apoptosis.The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway.Stringent spacing requirements for transcription activation by CRP.CX-4945 Induces Methuosis in Cholangiocarcinoma Cell Lines by a CK2-Independent MechanismHuman T cell responses to HPV 16 E2 generated with monocyte-derived dendritic cellsTranscription from the Escherichia coli melR promoter is dependent on the cyclic AMP receptor proteinCpG methylation and the binding of YY1 and ETS proteins to the Surf-1/Surf-2 bidirectional promoterYY1 is involved in the regulation of the bi-directional promoter of the Surf-1 and Surf-2 genesDNA binding and bending by the human papillomavirus type 16 E2 protein. Recognition of an extended binding siteMagnesium ions enhance the transfer of human papillomavirus E2 protein from non-specific to specific binding sitesMyc and YY1 mediate activation of the Surf-1 promoter in response to serum growth factors
P50
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