Glucolipotoxicity alters lipid partitioning and causes mitochondrial dysfunction, cholesterol, and ceramide deposition and reactive oxygen species production in INS832/13 ss-cells.
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Insulin resistance as a physiological defense against metabolic stress: implications for the management of subsets of type 2 diabetesThe Use of SGLT-2 Inhibitors in Type 2 Diabetes and Heart FailureIdentification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic β-cells and hepatocytesCombined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolismSphingolipids in obesity, type 2 diabetes, and metabolic disease.Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerolChronic glucolipotoxic conditions in pancreatic islets impair insulin secretion due to dysregulated calcium dynamics, glucose responsiveness and mitochondrial activity.Changes in mitochondrial carriers exhibit stress-specific signatures in INS-1Eβ-cells exposed to glucose versus fatty acids.Increased lipogenesis and stearate accelerate vascular calcification in calcifying vascular cellsRoles of Sphingolipid Metabolism in Pancreatic β Cell Dysfunction Induced by Lipotoxicity.High Intensity Interval Training Improves Glycaemic Control and Pancreatic β Cell Function of Type 2 Diabetes Patients.Pancreatic β-Cell Dysfunction in Diet-Induced Obese Mice: Roles of AMP-Kinase, Protein Kinase Cε, Mitochondrial and Cholesterol Metabolism, and Alterations in Gene ExpressionA role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell deathAICAR and Metformin Exert AMPK-dependent Effects on INS-1E Pancreatic β-cell Apoptosis via Differential Downstream Mechanisms.A systematic review of oxidative stress and safety of antioxidants in diabetes: focus on islets and their defense.Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic β-cellsCeramide formation as a target in beta-cell survival and function.Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction.Stigmasterol prevents glucolipotoxicity induced defects in glucose-stimulated insulin secretion.Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity.Increased oxidative stress and toxicity in ADH and CYP2E1 overexpressing human hepatoma VL-17A cells exposed to high glucose.Lipotoxicity is glucose-dependent in INS-1E cells but not in human islets and MIN6 cells.ABCA1 deficiency and cellular cholesterol accumulation increases islet amyloidogenesis in mice.Chronic Exposure to Proline Causes Aminoacidotoxicity and Impaired Beta-Cell Function: Studies In Vitro.Fatty Acids, Antioxidants and Physical Activity in Brain Aging.HSF1 acetylation decreases its transcriptional activity and enhances glucolipotoxicity-induced apoptosis in rat and human beta cells.CI-MPR deficiency enhances β-cell susceptibility to palmitate.Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6.Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells.Glucokinase mediates coupling of glycolysis to mitochondrial metabolism but not to beta cell damage at high glucose exposure levels.Sphingolipid regulators of cellular dysfunction in Type 2 diabetes mellitus: a systems overview.
P2860
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P2860
Glucolipotoxicity alters lipid partitioning and causes mitochondrial dysfunction, cholesterol, and ceramide deposition and reactive oxygen species production in INS832/13 ss-cells.
description
2010 nî lūn-bûn
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2010年の論文
@ja
2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
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2010年學術文章
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name
Glucolipotoxicity alters lipid ...... duction in INS832/13 ss-cells.
@en
Glucolipotoxicity alters lipid ...... duction in INS832/13 ss-cells.
@nl
type
label
Glucolipotoxicity alters lipid ...... duction in INS832/13 ss-cells.
@en
Glucolipotoxicity alters lipid ...... duction in INS832/13 ss-cells.
@nl
prefLabel
Glucolipotoxicity alters lipid ...... duction in INS832/13 ss-cells.
@en
Glucolipotoxicity alters lipid ...... duction in INS832/13 ss-cells.
@nl
P2093
P50
P356
P1433
P1476
Glucolipotoxicity alters lipid ...... duction in INS832/13 ss-cells.
@en
P2093
Annie Barbeau
Emilie Pepin
Isabel Maestre
Jean Buteau
José Iglesias
Marc Prentki
P304
P356
10.1210/EN.2009-1238
P407
P577
2010-05-05T00:00:00Z