about
Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimeraseNickel-catalysed aromatic Finkelstein reaction of aryl and heteroaryl bromidesSynthesis of 5-deazaflavin derivatives and their activation of p53 in cellsSynthesis and anti-protozoal activity of C2-substituted polyazamacrocycles.New iodinated quinoline-2-carboxamides for SPECT imaging of the translocator protein.Bacterial diaminopimelate metabolism as a target for antibiotic design.Synthesis and nicotinic binding of novel phenyl derivatives of UB-165. Identifying factors associated with alpha7 selectivity.Synthesis of two fluoro analogues of the nicotinic acetylcholine receptor agonist UB-165.Structural insights into stereochemical inversion by diaminopimelate epimerase: an antibacterial drug target.Synthesis of amino-substituted indanes and tetralins via consecutive multibond-forming tandem processes.A one-pot, three-step process for the diastereoselective synthesis of aminobicyclo[4.3.0]nonanes using consecutive palladium(II)- and ruthenium(II)-catalysis.Molecular tracers for the PET and SPECT imaging of disease.Synthesis and Evaluation of a Radioiodinated Tracer with Specificity for Poly(ADP-ribose) Polymerase-1 (PARP-1) in Vivo.Recent advances in the synthesis and application of fluorescent α-amino acids.Synthesis of novel benzamidine- and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasis.Synthesis, characterisation and anti-protozoal activity of carbamate-derived polyazamacrocycles.Intermolecular Aryl C-H Amination through Sequential Iron and Copper Catalysis.Stereoselective synthesis of the bicyclic guanidine alkaloid (+)-monanchorin.Preparation of anti-vicinal amino alcohols: asymmetric synthesis of D-erythro-sphinganine, (+)-spisulosine, and D-ribo-phytosphingosine.Synthesis of fluorescent enone derived alpha-amino acids.Nickel-mediated radioiodination of aryl and heteroaryl bromides: rapid synthesis of tracers for SPECT imaging.Versatile synthesis of 3,5-disubstituted 2-fluoropyridines and 2-pyridones.The first enantioselective synthesis of the amino acid, (2S,3S,4R)-gamma-hydroxyisoleucine using a palladium(II) catalysed 3,3-sigmatropic rearrangement.A novel 18F-labelled high affinity agent for PET imaging of the translocator protein.Iodine-123 labeled reboxetine analogues for imaging of noradrenaline transporter in brain using single photon emission computed tomography.Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter.A stereoselective synthesis of (+)-physoperuvine using a tandem aza-Claisen rearrangement and ring closing metathesis reaction.New iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter.Rapid and efficient radiosynthesis of [123I]I-PK11195, a single photon emission computed tomography tracer for peripheral benzodiazepine receptors.Stereoselective synthesis of (2S,3R)- and (2R,3S)-iodoreboxetine; potential SPECT imaging agents for the noradrenaline transporter.Stereoselective beta-hydroxy-alpha-amino acid synthesis via an ether-directed, palladium-catalysed aza-Claisen rearrangement.The stereoselective synthesis of aziridine analogues of diaminopimelic acid (DAP) and their interaction with dap epimerase.Rapid Iododeboronation with and without Gold Catalysis: Application to Radiolabelling of Arenes.Structural diversification of the aminobicyclo[4.3.0]nonane skeleton using alkynylsilyl-derived allylic trichloroacetimidates.Access to 2,6-Disubstituted 4-Oxopiperidines Using a 6-Endo-trig Cyclization: Stereoselective Synthesis of Spruce Alkaloid and (+)-241D.Iron(III)-Catalyzed Chlorination of Activated Arenes.One-Pot Asymmetric Synthesis of Alkylidene 1-Alkylindan-1-ols Using Brønsted Acid and Palladium Catalysis.¹²³I-NKJ64: a novel single photon emission computed tomography radiotracer for imaging the noradrenaline transporter in brain.Ether-directed, stereoselective aza-Claisen rearrangements: synthesis of the piperidine alkaloid, alpha-conhydrine.Asymmetric synthesis of cis-aminocyclopentenols, building blocks for medicinal chemistry.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Andrew Sutherland
@ast
Andrew Sutherland
@en
Andrew Sutherland
@es
Andrew Sutherland
@nl
type
label
Andrew Sutherland
@ast
Andrew Sutherland
@en
Andrew Sutherland
@es
Andrew Sutherland
@nl
prefLabel
Andrew Sutherland
@ast
Andrew Sutherland
@en
Andrew Sutherland
@es
Andrew Sutherland
@nl
P106
P1153
7103407073
P21
P31
P496
0000-0001-7907-5766