The conformational dynamics of the mitochondrial Hsp70 chaperone.
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Insights into the molecular mechanism of allostery in Hsp70s.BiP and its nucleotide exchange factors Grp170 and Sil1: mechanisms of action and biological functionsMolecular mechanism of allosteric communication in Hsp70 revealed by molecular dynamics simulationsBiochemical and structural studies on the high affinity of Hsp70 for ADPAllosteric opening of the polypeptide-binding site when an Hsp70 binds ATPRole of the AAA protease Yme1 in folding of proteins in the intermembrane space of mitochondria.Allostery in the Hsp70 chaperone proteinsClose and Allosteric Opening of the Polypeptide-Binding Site in a Human Hsp70 Chaperone BiPHSPA8/HSC70 chaperone protein: structure, function, and chemical targeting.Kinks, loops, and protein folding, with protein A as an example.Pathways of allosteric regulation in Hsp70 chaperones.Methylation-controlled J-protein MCJ acts in the import of proteins into human mitochondria.Key features of an Hsp70 chaperone allosteric landscape revealed by ion-mobility native mass spectrometry and double electron-electron resonanceRole of the loop L4,5 in allosteric regulation in mtHsp70s: in vivo significance of domain communication and its implications in protein translocationModeling Hsp70/Hsp40 interaction by multi-scale molecular simulations and coevolutionary sequence analysisCombining MFD and PIE for accurate single-pair Förster resonance energy transfer measurements.Single-molecule spectroscopy reveals chaperone-mediated expansion of substrate protein.Dissection of structural and functional requirements that underlie the interaction of ERdj3 protein with substrates in the endoplasmic reticulum.Molecular chaperone dysfunction in neurodegenerative diseases and effects of curcumin.Allosteric signal transmission in the nucleotide-binding domain of 70-kDa heat shock protein (Hsp70) molecular chaperonesCommon functionally important motions of the nucleotide-binding domain of Hsp70Decipher the mechanisms of protein conformational changes induced by nucleotide binding through free-energy landscape analysis: ATP binding to Hsp70.An RNA aptamer specific to Hsp70-ATP conformation inhibits its ATPase activity independent of Hsp40.Hsp70 forms antiparallel dimers stabilized by post-translational modifications to position clients for transfer to Hsp90.Dancing through Life: Molecular Dynamics Simulations and Network-Centric Modeling of Allosteric Mechanisms in Hsp70 and Hsp110 Chaperone Proteins.Simulation of the opening and closing of Hsp70 chaperones by coarse-grained molecular dynamicsComputational Analysis of Residue Interaction Networks and Coevolutionary Relationships in the Hsp70 Chaperones: A Community-Hopping Model of Allosteric Regulation and CommunicationAptamer-Enabled Manipulation of the Hsp70 Chaperone System Suggests a Novel Strategy for Targeted Ubiquitination.Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2Dynamical Structures of Hsp70 and Hsp70-Hsp40 Complexes.Two distinct membrane potential-dependent steps drive mitochondrial matrix protein translocation.Mechanisms of protein sorting in mitochondriaProtein translocation channel of mitochondrial inner membrane and matrix-exposed import motor communicate via two-domain coupling protein.Structural mechanisms of chaperone mediated protein disaggregation.Mitochondrial protein import in trypanosomes: Expect the unexpected.The chaperone toolbox at the single-molecule level: From clamping to confining.Reactivation of protein aggregates by mortalin and Tid1--the human mitochondrial Hsp70 chaperone system.Monitoring conformational heterogeneity of the lid of DnaK substrate-binding domain during its chaperone cycle.Mitochondrial heat shock protein (Hsp) 70 and Hsp10 cooperate in the formation of Hsp60 complexes.Effects of Hofmeister ions on the α-helical structure of proteins.
P2860
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P2860
The conformational dynamics of the mitochondrial Hsp70 chaperone.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh-hant
name
The conformational dynamics of the mitochondrial Hsp70 chaperone.
@en
The conformational dynamics of the mitochondrial Hsp70 chaperone.
@nl
type
label
The conformational dynamics of the mitochondrial Hsp70 chaperone.
@en
The conformational dynamics of the mitochondrial Hsp70 chaperone.
@nl
prefLabel
The conformational dynamics of the mitochondrial Hsp70 chaperone.
@en
The conformational dynamics of the mitochondrial Hsp70 chaperone.
@nl
P2093
P1433
P1476
The conformational dynamics of the mitochondrial Hsp70 chaperone.
@en
P2093
Claus A M Seidel
Karin Waegemann
Koyeli Mapa
Martin Sikor
Stanislav Kalinin
Volodymyr Kudryavtsev
Walter Neupert
P304
P356
10.1016/J.MOLCEL.2010.03.010
P577
2010-04-01T00:00:00Z