about
RecBCD enzyme and the repair of double-stranded DNA breaksCrystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanismInsights into Chi recognition from the structure of an AddAB-type helicase-nuclease complexStructural basis for translocation by AddAB helicase-nuclease and its arrest at χ sites.Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaksStructure and mechanism of helicases and nucleic acid translocasesVisualizing helicases unwinding DNA at the single molecule levelOn the mechanism of recombination hotspot scanning during double-stranded DNA break resection.A new method for inferring hidden markov models from noisy time sequences.AFM volumetric methods for the characterization of proteins and nucleic acids.Monomeric PcrA helicase processively unwinds plasmid lengths of DNA in the presence of the initiator protein RepD.The AddAB helicase-nuclease catalyses rapid and processive DNA unwinding using a single Superfamily 1A motor domain.The conserved C-terminus of the PcrA/UvrD helicase interacts directly with RNA polymerase.Uncoupling DNA translocation and helicase activity in PcrA: direct evidence for an active mechanism.Probing DNA helicase kinetics with temperature-controlled magnetic tweezersMolecular determinants responsible for recognition of the single-stranded DNA regulatory sequence, χ, by RecBCD enzymeAlteration of χ recognition by RecBCD reveals a regulated molecular latch and suggests a channel-bypass mechanism for biological control.Fluorescent single-stranded DNA binding protein as a probe for sensitive, real-time assays of helicase activity.Protein modification for single molecule fluorescence microscopy.The processing of double-stranded DNA breaks for recombinational repair by helicase-nuclease complexes.Iron-sulphur clusters in nucleic acid processing enzymes.The conflict between DNA replication and transcription.Superfamily 1 helicases .Single molecule approaches to monitor the recognition and resection of double-stranded DNA breaks during homologous recombination.Direct measurement of single-stranded DNA translocation by PcrA helicase using the fluorescent base analogue 2-aminopurine.The unstructured C-terminal extension of UvrD interacts with UvrB, but is dispensable for nucleotide excision repair.Rep provides a second motor at the replisome to promote duplication of protein-bound DNA.Structural basis for the inhibition of RecBCD by Gam and its synergistic antibacterial effect with quinolones.Inhibiting translation elongation can aid genome duplication in Escherichia coli.Escherichia coli ribosomal protein L3 stimulates the helicase activity of the Bacillus stearothermophilus PcrA helicase.Site-directed mutagenesis of motif III in PcrA helicase reveals a role in coupling ATP hydrolysis to strand separation.Recombination hotspots attenuate the coupled ATPase and translocase activities of an AddAB-type helicase-nuclease.Chi hotspots trigger a conformational change in the helicase-like domain of AddAB to activate homologous recombination.Repercussions of DNA tracking by the type IC restriction endonuclease EcoR124I on linear, circular and catenated substrates.Engineering a reagentless biosensor for single-stranded DNA to measure real-time helicase activity in Bacillus.The structure and function of an RNA polymerase interaction domain in the PcrA/UvrD helicase.Specific and non-specific interactions of ParB with DNA: implications for chromosome segregation.An iron-sulfur cluster is essential for the binding of broken DNA by AddAB-type helicase-nucleases.Translocation by the RecB motor is an absolute requirement for {chi}-recognition and RecA protein loading by RecBCD enzyme.RecBCD enzyme is a bipolar DNA helicase.
P50
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P50
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