Assessing the stability of Alzheimer's amyloid protofibrils using molecular dynamics.
about
Ubiquitous amyloidsSelective Monocationic Inhibitors of Neuronal Nitric Oxide Synthase. Binding Mode Insights from Molecular Dynamics SimulationsMechanism of Tc toxin action revealed in molecular detailStructure and dynamics of amyloid-β segmental polymorphismsInvestigation of the effect of erythrosine B on amyloid beta peptide using molecular modeling.Electrical Stimulus Controlled Binding/Unbinding of Human Thrombin-Aptamer Complex.Structural and fluctuational difference between two ends of Aβ amyloid fibril: MD simulations predict only one end has open conformations.The structure of misfolded amyloidogenic dimers: computational analysis of force spectroscopy data.β sheets not required: combined experimental and computational studies of self-assembly and gelation of the ester-containing analogue of an Fmoc-dipeptide hydrogelator.Strength of hydrogen bond network takes crucial roles in the dissociation process of inhibitors from the HIV-1 protease binding pocket.Interface matters: the stiffness route to stability of a thermophilic tetrameric malate dehydrogenase.Insight into amyloid structure using chemical probes.In silico insights into protein-protein interactions and folding dynamics of the saposin-like domain of Solanum tuberosum aspartic protease.Virtual screening of specific insulin-like growth factor 1 receptor (IGF1R) inhibitors from the National Cancer Institute (NCI) molecular databaseEarly Events in the Amyloid Formation of the A546T Mutant of Transforming Growth Factor β-Induced Protein in Corneal Dystrophies Compared to the Nonfibrillating R555W and R555Q MutantsEmbedding Aβ42 in heterogeneous membranes depends on cholesterol asymmetriesFree Energy Landscape of Lipid Interactions with Regulatory Binding Sites on the Transmembrane Domain of the EGF ReceptorMolecular Dynamics Simulations of the Permeation of Bisphenol A and Pore Formation in a Lipid MembraneCooperative Binding of Cyclodextrin Dimers to Isoflavone Analogues Elucidated by Free Energy Calculations.The role of molecular simulations in the development of inhibitors of amyloid β-peptide aggregation for the treatment of Alzheimer's diseaseMolecular dynamics simulations reveal the protective role of cholesterol in β-amyloid protein-induced membrane disruptions in neuronal membrane mimics.Insights into the mechanism of interaction between trehalose-conjugated beta-sheet breaker peptides and Aβ(1-42) fibrils by molecular dynamics simulations.Decoupled side chain and backbone dynamics for proton translocation - M2 of influenza A.Elongation affinity, activation barrier, and stability of Aβ42 oligomers/fibrils in physiological saline.Dissecting the structural determinants for the difference in mechanical stability of silk and amyloid beta-sheet stacks.Mechanism of NTP Binding to the Active Site of T7 RNA Polymerase Revealed by Free-Energy Simulation.Molecular dynamics simulation study of the "stay or leave" problem for two magnesium ions in gene transcription.Molecular mechanism of misfolding and aggregation of Aβ(13-23).Pinpointing proline substitution to be responsible for the loss of amyloidogenesis in IAPP.In silico investigation and targeting of amyloid β oligomers of different size.The role of solvent exclusion in the interaction between D124 and the metal site in SOD1: implications for ALS.Exploring the essential collective dynamics of interacting proteins: application to prion protein dimers.Relationship between helix stability and binding affinities: molecular dynamics simulations of Bfl-1/A1-binding pro-apoptotic BH3 peptide helices in explicit solvent.Amino acids and proteins at ZnO-water interfaces in molecular dynamics simulations.Probing oligomerization of amyloid beta peptide in silico.Simulation of Reversible Protein-Protein Binding and Calculation of Binding Free Energies Using Perturbed Distance Restraints.Evaluation of Sox2 binding affinities for distinct DNA patterns using steered molecular dynamics simulation.Investigation of the interaction of amyloid β peptide (11-42) oligomers with a 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) membrane using molecular dynamics simulation.Energetics Underlying Twist Polymorphisms in Amyloid Fibrils.Molecular dynamics simulations and novel drug discovery.
P2860
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P2860
Assessing the stability of Alzheimer's amyloid protofibrils using molecular dynamics.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh-hant
name
Assessing the stability of Alzheimer's amyloid protofibrils using molecular dynamics.
@en
Assessing the stability of Alzheimer's amyloid protofibrils using molecular dynamics.
@nl
type
label
Assessing the stability of Alzheimer's amyloid protofibrils using molecular dynamics.
@en
Assessing the stability of Alzheimer's amyloid protofibrils using molecular dynamics.
@nl
prefLabel
Assessing the stability of Alzheimer's amyloid protofibrils using molecular dynamics.
@en
Assessing the stability of Alzheimer's amyloid protofibrils using molecular dynamics.
@nl
P356
P1476
Assessing the stability of Alzheimer's amyloid protofibrils using molecular dynamics.
@en
P304
P356
10.1021/JP9110794
P407
P577
2010-02-01T00:00:00Z