about
Experimental characterization of the human non-sequence-specific nucleic acid interactomePIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancersSpecific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding ModesInhibition of the SR protein-phosphorylating CLK kinases of Plasmodium falciparum impairs blood stage replication and malaria transmissionArtemisinins Target GABAA Receptor Signaling and Impair α Cell IdentityA cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis.Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L BromodomainsThe promise and peril of chemical probes.Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling.Global survey of the immunomodulatory potential of common drugs.After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders.Discovery of a PCAF Bromodomain Chemical Probe.Thiazolidine derivatives as potent and selective inhibitors of the PIM kinase family.Evaluating the promiscuous nature of tyrosine kinase inhibitors assessed in A431 epidermoid carcinoma cells by both chemical- and phosphoproteomics.Regulation of pro-angiogenic tissue factor expression in hypoxia-induced human lung cancer cells.Building and exploring an integrated human kinase network: global organization and medical entry points.Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions.Lapatinib potentiates cytotoxicity of YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporterInhibition of NAD+-dependent histone deacetylases (sirtuins) causes growth arrest and activates both apoptosis and autophagy in the pathogenic protozoan Trypanosoma cruzi.Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins).Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action.Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement.Nilotinib-induced vasculopathy: identification of vascular endothelial cells as a primary target site.Target engagement: Shining a light.KH-TFMDI, a novel sirtuin inhibitor, alters the cytoskeleton and mitochondrial metabolism promoting cell death in Leishmania amazonensis.Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design.Discovery of an MLLT1/3 YEATS Domain Chemical ProbeChemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX InhibitorsA chemical biology toolbox to study protein methyltransferases and epigenetic signalingProfiling of Small Molecules by Chemical ProteomicsRe-Evaluating the Mechanism of Action of α,β-Unsaturated Carbonyl DUB Inhibitors b-AP15 and VLX1570: A Paradigmatic Example of Unspecific Protein Cross-linking with Michael Acceptor Motif-Containing DrugsA Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin FunctionSmall molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signalingAlterations on growth and cell organization of Giardia intestinalis trophozoites after treatment with KH-TFMDI, a novel class III histone deacetylase inhibitorFragment-based discovery of a chemical probe for the PWWP1 domain of NSD3Rapid Covalent-Probe Discovery by Electrophile-Fragment ScreeningRegulation of influenza A virus mRNA splicing by CLK1Design, Synthesis and Characterization of Covalent KDM5 InhibitorsQuantifying CDK inhibitor selectivity in live cells
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description
hulumtues
@sq
onderzoeker
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researcher
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ricercatore
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հետազոտող
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name
Kilian Huber
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Kilian Huber
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Kilian Huber
@es
Kilian Huber
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Kilian Huber
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type
label
Kilian Huber
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Kilian Huber
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Kilian Huber
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Kilian Huber
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Kilian Huber
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altLabel
Kilian V. M. Huber
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prefLabel
Kilian Huber
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Kilian Huber
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Kilian Huber
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Kilian Huber
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Kilian Huber
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P214
P1053
L-6921-2015
P106
P1153
22734209500
P21
P213
0000 0000 5783 316X
P214
P2798
P31
P3829
P496
0000-0002-1103-5300
P734
P7859
viaf-81035303