Broken helix in vesicle and micelle-bound alpha-synuclein: insights from site-directed spin labeling-EPR experiments and MD simulations.
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Molecular determinants of α-synuclein mutants' oligomerization and membrane interactionsStructure of membrane-bound alpha-synuclein from site-directed spin labeling and computational refinementSystematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activitiesMembrane remodeling by amyloidogenic and non-amyloidogenic proteins studied by EPR.Biophysics of α-synuclein membrane interactions.Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopyThe lipid-binding domain of wild type and mutant alpha-synuclein: compactness and interconversion between the broken and extended helix forms.Probing the micelle-bound aggregation-prone state of α-synuclein with (19)F NMR spectroscopyThe N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding.Alpha-synuclein function and dysfunction on cellular membranes.Alpha-synuclein populates both elongated and broken helix states on small unilamellar vesicles.Structural and dynamical insights into the membrane-bound α-synuclein.Parkinson's Protein α-Synuclein Binds Efficiently and with a Novel Conformation to Two Natural Membrane MimicsCharacterization of a disordered protein during micellation: interactions of α-synuclein with sodium dodecyl sulfate.Remodeling of lipid vesicles into cylindrical micelles by α-synuclein in an extended α-helical conformation.Membrane-bound α-synuclein interacts with glucocerebrosidase and inhibits enzyme activity.Preparation and Characterization of Stable α-Synuclein Lipoprotein ParticlesCurvature dynamics of alpha-synuclein familial Parkinson disease mutants: molecular simulations of the micelle- and bilayer-bound forms.Interplay of alpha-synuclein binding and conformational switching probed by single-molecule fluorescence.Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopyDeducing conformational variability of intrinsically disordered proteins from infrared spectroscopy with Bayesian statistics.Charge State Dependent Fragmentation of Gaseous α-Synuclein Cations via Ion Trap and Beam-Type Collisional Activation.Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation.Computational approaches to understanding protein aggregation in neurodegeneration.Folding and misfolding of alpha-synuclein on membranes.Hunting the chameleon: structural conformations of the intrinsically disordered protein alpha-synuclein.Using NMR chemical shifts to calculate the propensity for structural order and disorder in proteins.Conformation, self-aggregation, and membrane interaction of peptaibols as studied by pulsed electron double resonance spectroscopy.Alpha-synuclein binds large unilamellar vesicles as an extended helixAlpha-synuclein mediates alterations in membrane conductance: a potential role for alpha-synuclein oligomers in cell vulnerability.Alteration of the alpha-synuclein folding landscape by a mutation related to Parkinson's disease.Specificity and kinetics of alpha-synuclein binding to model membranes determined with fluorescent excited state intramolecular proton transfer (ESIPT) probeThe influence of vesicle size and composition on alpha-synuclein structure and stability.19F NMR studies of α-synuclein-membrane interactions.Membrane-bound alpha-synuclein forms an extended helix: long-distance pulsed ESR measurements using vesicles, bicelles, and rodlike micelles.Self-association of an enantiopure β-pentapeptide in nematic liquid crystals.Synthesis and conformational properties of a TOAC doubly spin-labeled analog of the medium-length, membrane active peptaibiotic ampullosporin A as revealed by CD, fluorescence, and EPR spectroscopies.A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease.Structure and dynamics of the extended-helix state of alpha-synuclein: Intrinsic lability of the linker region.Interaction of hydrophobic and amphipathic antimicrobial peptides with lipid bicelles.
P2860
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P2860
Broken helix in vesicle and micelle-bound alpha-synuclein: insights from site-directed spin labeling-EPR experiments and MD simulations.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Broken helix in vesicle and mi ...... xperiments and MD simulations.
@en
Broken helix in vesicle and mi ...... xperiments and MD simulations.
@nl
type
label
Broken helix in vesicle and mi ...... xperiments and MD simulations.
@en
Broken helix in vesicle and mi ...... xperiments and MD simulations.
@nl
prefLabel
Broken helix in vesicle and mi ...... xperiments and MD simulations.
@en
Broken helix in vesicle and mi ...... xperiments and MD simulations.
@nl
P2093
P50
P356
P1476
Broken helix in vesicle and mi ...... experiments and MD simulations
@en
P2093
Anna Lisa Maniero
Fabio Tombolato
Marco Bisaglia
Stefano Mammi
P304
P356
10.1021/JA8010429
P407
P577
2008-05-06T00:00:00Z