Dissecting the cofactor-dependent and independent bindings of PDE4 inhibitors.
about
Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesisFragment-Based Screening for Inhibitors of PDE4A Using Enthalpy Arrays and X-ray CrystallographyStereoselective synthesis of novel pyrazole derivatives using tert-butansulfonamide as a chiral auxiliaryIn vitro PKA phosphorylation-mediated human PDE4A4 activationCharacterization of a catalytic ligand bridging metal ions in phosphodiesterases 4 and 5 by molecular dynamics simulations and hybrid quantum mechanical/molecular mechanical calculations.PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalizationPhosphodiesterase-4 inhibitors as a novel approach for the treatment of respiratory disease: cilomilast.Enantiomer discrimination illustrated by the high resolution crystal structures of type 4 phosphodiesteraseNovel 5,6-dihydropyrazolo[3,4-E][1,4]diazepin-4 (1H)-one derivatives for the treatment of asthma and chronic obstructive pulmonary disease.
P2860
Q24553313-2B6FA49E-C5F3-41EE-9F13-9225A8B3333CQ27676592-D771F97A-57F2-44F3-AA72-2AF18FFEB185Q27677514-76B24ED4-83CC-45E2-9058-CAF079FD656BQ28202278-8D1FB0EA-9475-4FE2-A800-A6EDE116F678Q34984650-7ABDA8F6-B68A-4010-AF5E-4AFE760283F9Q35005680-50F9F46A-9C61-491A-8365-4FDD5229758DQ36677411-BA86B671-99C6-4855-A1AF-F33DBA0539F3Q36855547-FA1801D0-5CDB-4AAA-8823-991B5C068557Q42975073-F5AAC459-0999-45ED-89E5-116E915B3C01
P2860
Dissecting the cofactor-dependent and independent bindings of PDE4 inhibitors.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Dissecting the cofactor-dependent and independent bindings of PDE4 inhibitors.
@en
Dissecting the cofactor-dependent and independent bindings of PDE4 inhibitors.
@nl
type
label
Dissecting the cofactor-dependent and independent bindings of PDE4 inhibitors.
@en
Dissecting the cofactor-dependent and independent bindings of PDE4 inhibitors.
@nl
prefLabel
Dissecting the cofactor-dependent and independent bindings of PDE4 inhibitors.
@en
Dissecting the cofactor-dependent and independent bindings of PDE4 inhibitors.
@nl
P2093
P356
P1433
P1476
Dissecting the cofactor-dependent and independent bindings of PDE4 inhibitors
@en
P2093
B Bobechko
F Laliberté
J Van Hamme
M J Gresser
P304
10179-10186
P356
10.1021/BI010096P
P407
P577
2001-08-01T00:00:00Z