Definition of a dioxin receptor mutant that is a constitutive activator of transcription: delineation of overlapping repression and ligand binding functions within the PAS domain.
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Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factorsRepression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear translocatorAryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cellsRole of Aryl Hydrocarbon Receptor in Circadian Clock Disruption and Metabolic DysfunctionAryl hydrocarbon receptor is activated by glucose and regulates the thrombospondin-1 gene promoter in endothelial cellsDeciphering Dimerization Modes of PAS Domains: Computational and Experimental Analyses of the AhR:ARNT Complex Reveal New Insights Into the Mechanisms of AhR TransformationCardiac myocyte-specific AHR activation phenocopies TCDD-induced toxicity in zebrafish.Malignant transformation of mammary epithelial cells by ectopic overexpression of the aryl hydrocarbon receptorDetection of the TCDD binding-fingerprint within the Ah receptor ligand binding domain by structurally driven mutagenesis and functional analysis.Structural and functional characterization of the aryl hydrocarbon receptor ligand binding domain by homology modeling and mutational analysisA novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosisA constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors.A dominant negative zebrafish Ahr2 partially protects developing zebrafish from dioxin toxicity.Identification of residues in the N-terminal PAS domains important for dimerization of Arnt and AhR.The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells.Specific blockage of ligand-induced degradation of the Ah receptor by proteasome but not calpain inhibitors in cell culture lines from different speciesAnthracycline inhibits recruitment of hypoxia-inducible transcription factors and suppresses tumor cell migration and cardiac angiogenic response in the host.AHR Function in Lymphocytes: Emerging ConceptsActivation of the aryl hydrocarbon receptor sensitizes mice to nonalcoholic steatohepatitis by deactivating mitochondrial sirtuin deacetylase Sirt3.Hepatic Aryl Hydrocarbon Receptor Attenuates Fibroblast Growth Factor 21 ExpressionOmeprazole Inhibits Pancreatic Cancer Cell Invasion through a Nongenomic Aryl Hydrocarbon Receptor Pathway.Knockdown of aberrantly upregulated aryl hydrocarbon receptor reduces tumor growth and metastasis of MDA-MB-231 human breast cancer cell line.The active form of human aryl hydrocarbon receptor (AHR) repressor lacks exon 8, and its Pro 185 and Ala 185 variants repress both AHR and hypoxia-inducible factorGenetic variation at aryl hydrocarbon receptor (AHR) loci in populations of Atlantic killifish (Fundulus heteroclitus) inhabiting polluted and reference habitats.Structural modeling of the AhR:ARNT complex in the bHLH-PASA-PASB region elucidates the key determinants of dimerization.Dioxin receptor expression inhibits basal and transforming growth factor β-induced epithelial-to-mesenchymal transition.Aryl hydrocarbon receptor inhibition downregulates the TGF-beta/Smad pathway in human glioblastoma cells.The LMP1 promoter can be transactivated directly by NF-kappaB.Unique and overlapping transcriptional roles of arylhydrocarbon receptor nuclear translocator (Arnt) and Arnt2 in xenobiotic and hypoxic responses.Activation of aryl hydrocarbon receptor dissociates fatty liver from insulin resistance by inducing fibroblast growth factor 21.Impaired dendritic growth and positioning of cortical pyramidal neurons by activation of aryl hydrocarbon receptor signaling in the developing mouseRole of the Per/Arnt/Sim domains in ligand-dependent transformation of the aryl hydrocarbon receptor.Contribution of the Per/Arnt/Sim (PAS) domains to DNA binding by the basic helix-loop-helix PAS transcriptional regulators.A constitutively active arylhydrocarbon receptor induces growth inhibition of jurkat T cells through changes in the expression of genes related to apoptosis and cell cycle arrest.The dioxin/aryl hydrocarbon receptor mediates downregulation of osteopontin gene expression in a mouse model of gastric tumourigenesis.Expression of constitutively-active aryl hydrocarbon receptor in T-cells enhances the down-regulation of CD62L, but does not alter expression of CD25 or suppress the allogeneic CTL response.Constitutively active aryl hydrocarbon receptor expressed in T cells increases immunization-induced IFN-gamma production in mice but does not suppress T(h)2-cytokine production or antibody production.The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells.Novel DNA binding by a basic helix-loop-helix protein. The role of the dioxin receptor PAS domain.Nuclear transport of the human aryl hydrocarbon receptor and subsequent gene induction relies on its residue histidine 291.
P2860
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P2860
Definition of a dioxin receptor mutant that is a constitutive activator of transcription: delineation of overlapping repression and ligand binding functions within the PAS domain.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Definition of a dioxin recepto ...... nctions within the PAS domain.
@en
Definition of a dioxin recepto ...... nctions within the PAS domain.
@nl
type
label
Definition of a dioxin recepto ...... nctions within the PAS domain.
@en
Definition of a dioxin recepto ...... nctions within the PAS domain.
@nl
prefLabel
Definition of a dioxin recepto ...... nctions within the PAS domain.
@en
Definition of a dioxin recepto ...... nctions within the PAS domain.
@nl
P2093
P2860
P356
P1476
Definition of a dioxin recepto ...... nctions within the PAS domain.
@en
P2093
Poellinger L
Whitelaw ML
P2860
P304
41841-41849
P356
10.1074/JBC.M105607200
P407
P577
2001-09-10T00:00:00Z