Immunohistochemical localization of group I and II metabotropic glutamate receptors in control and amyotrophic lateral sclerosis human spinal cord: upregulation in reactive astrocytes.
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Recent progress in the discovery of small molecules for the treatment of amyotrophic lateral sclerosis (ALS)Astrocytes As the Main Players in Primary Degenerative Disorders of the Human Central Nervous SystemMetabotropic glutamate receptor-mediated signaling in neurogliaNeuronal matrix metalloproteinase-9 is a determinant of selective neurodegenerationFocal degeneration of astrocytes in amyotrophic lateral sclerosis.Optimized and efficient preparation of astrocyte cultures from rat spinal cordCRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs.Axotomy-induced target disconnection promotes an additional death mechanism involved in motoneuron degeneration in amyotrophic lateral sclerosis transgenic mice.Astrocyte-derived BDNF supports myelin protein synthesis after cuprizone-induced demyelination.Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity.Activation of NAD(P)H oxidase by tryptophan-derived 3-hydroxykynurenine accelerates endothelial apoptosis and dysfunction in vivo.Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins.Glial proliferation and metabotropic glutamate receptor expression in amyotrophic lateral sclerosis.Hypo-anxious phenotype of adolescent offspring prenatally exposed to LPS is associated with reduced mGluR5 expression in hippocampus.Distinct physiological roles of the Gq-coupled metabotropic glutamate receptors Co-expressed in the same neuronal populations.Concurrent multiple sclerosis and amyotrophic lateral sclerosis: where inflammation and neurodegeneration meet?mGluRI targets microglial activation and selectively prevents neuronal cell engulfment through Akt and caspase dependent pathwaysPET imaging studies show enhanced expression of mGluR5 and inflammatory response during progressive degeneration in ALS mouse model expressing SOD1-G93A geneThe PDZ scaffold NHERF-2 interacts with mGluR5 and regulates receptor activity.Driving cellular plasticity and survival through the signal transduction pathways of metabotropic glutamate receptors.Astrocyte dysfunction in neurological disorders: a molecular perspective.Translational Concepts of mGluR5 in Synaptic Diseases of the BrainIntracellular mGluR5 plays a critical role in neuropathic painExcitotoxicity and amyotrophic lateral sclerosis.Contribution of opioid and metabotropic glutamate receptor mechanisms to inhibition of bladder overactivity by tibial nerve stimulation.Therapeutic promise and principles: metabotropic glutamate receptorsMetabotropic glutamate receptors as targets for multipotential treatment of neurological disorders.Central sensitization: a generator of pain hypersensitivity by central neural plasticity.Genetic ablation of IP3 receptor 2 increases cytokines and decreases survival of SOD1G93A mice.Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions.Sex differences in the glutamate signaling pathway in juvenile rats.Metabotropic glutamate receptor 5 - a promising target in drug development and neuroimaging.Neuroplasticity of ascending and descending pathways after somatosensory system injury: reviewing knowledge to identify neuropathic pain therapeutic targets.Positron emission tomography in amyotrophic lateral sclerosis: Towards targeting of molecular pathological hallmarks.Activation of group I metabotropic glutamate receptors modulates locomotor-related motoneuron output in mice.Glutamate elicits release of BDNF from basal forebrain astrocytes in a process dependent on metabotropic receptors and the PLC pathway.Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study.mGluR5 protect astrocytes from ischemic damage in postnatal CNS white matter.Activation of group II mGlu receptors inhibits voltage-gated Ca2+ currents in myenteric neurons.Neurotensin enhances glutamate excitotoxicity in mesencephalic neurons in primary culture.
P2860
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P2860
Immunohistochemical localization of group I and II metabotropic glutamate receptors in control and amyotrophic lateral sclerosis human spinal cord: upregulation in reactive astrocytes.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Immunohistochemical localizati ...... lation in reactive astrocytes.
@en
Immunohistochemical localizati ...... lation in reactive astrocytes.
@nl
type
label
Immunohistochemical localizati ...... lation in reactive astrocytes.
@en
Immunohistochemical localizati ...... lation in reactive astrocytes.
@nl
prefLabel
Immunohistochemical localizati ...... lation in reactive astrocytes.
@en
Immunohistochemical localizati ...... lation in reactive astrocytes.
@nl
P2093
P921
P1433
P1476
Immunohistochemical localizati ...... ulation in reactive astrocytes
@en
P2093
P304
P356
10.1016/S0306-4522(01)00181-6
P407
P577
2001-01-01T00:00:00Z