The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene.
about
ABL tyrosine kinases: evolution of function, regulation, and specificityCbl-ArgBP2 complex mediates ubiquitination and degradation of c-AblThe (6;9) chromosome translocation, associated with a specific subtype of acute nonlymphocytic leukemia, leads to aberrant transcription of a target gene on 9q34Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemiaMolecular cloning of Ian4: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activityThe t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger proteinTyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOSAssociation of HLA Class I and Class II genes with bcr-abl transcripts in leukemia patients with t(9;22) (q34;q11)Chronic myeloid leukemia: reminiscences and dreamsRegulation of mitochondrial functions by protein phosphorylation and dephosphorylationGAB2--a scaffolding protein in cancerAutophagy in malignant transformation and cancer progressionSystems genetics for drug target discoveryTransformation of myeloid leukemia cells to cytokine independence by Bcr-Abl is suppressed by kinase-defective HckCRKL binding to BCR-ABL and BCR-ABL transformationEngagement of the CrkL adaptor in interferon alpha signalling in BCR-ABL-expressing cellsThe interaction of the Bcr-Abl tyrosine kinase with the Src kinase Hck is mediated by multiple binding domainsExpression cloning of protein targets for 3-phosphorylated phosphoinositidesRole of ABL family kinases in cancer: from leukaemia to solid tumoursInhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexesc-Abl-deficient mice exhibit reduced numbers of peritoneal B-1 cells and defects in BCR-induced B cell activationNovel Acylguanidine Derivatives Targeting Smoothened Induce Antiproliferative and Pro-Apoptotic Effects in Chronic Myeloid Leukemia CellsAbl kinases are required for vascular function, Tie2 expression, and angiopoietin-1-mediated survivalDefying c-Abl signaling circuits through small allosteric compounds.Phosphorylation of Dok1 by Abl family kinases inhibits CrkI transforming activity.Two-state dynamics of the SH3-SH2 tandem of Abl kinase and the allosteric role of the N-capFunctional mechanisms and roles of adaptor proteins in abl-regulated cytoskeletal actin dynamics.Signal transduction and cellular functions of the TEL/ARG oncoprotein.The Lck binding domain of herpesvirus saimiri tip-484 constitutively activates Lck and STAT3 in T cells.Interactions of p62(dok) with p210(bcr-abl) and Bcr-Abl-associated proteins.Interactions of CBL with BCR-ABL and CRKL in BCR-ABL-transformed myeloid cells.Requirement of c-Myb for p210(BCR/ABL)-dependent transformation of hematopoietic progenitors and leukemogenesisMolecular mechanisms of cancer.Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data.Findings made in gene panel to whole genome sequencing: data, knowledge, ethics - and consequences?Juvenile chronic myeloid leukemia: oncogene characterization.Emerging drugs for chronic myeloid leukemia.Heterogeneity of genomic fusion of BCR and ABL in Philadelphia chromosome-positive acute lymphoblastic leukemia.Significance of BCR-ABL transcripts in bone marrow aspirates of Philadelphia-negative essential thrombocythemia patients.Clinical targeting of mutated and wild-type protein tyrosine kinases in cancer.
P2860
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P2860
The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene.
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年学术文章
@wuu
1986年学术文章
@zh
1986年学术文章
@zh-cn
1986年学术文章
@zh-hans
1986年学术文章
@zh-my
1986年学术文章
@zh-sg
1986年學術文章
@yue
1986年學術文章
@zh-hant
name
The chronic myelogenous leukem ...... ct of the bcr/abl hybrid gene.
@en
The chronic myelogenous leukem ...... ct of the bcr/abl hybrid gene.
@nl
type
label
The chronic myelogenous leukem ...... ct of the bcr/abl hybrid gene.
@en
The chronic myelogenous leukem ...... ct of the bcr/abl hybrid gene.
@nl
prefLabel
The chronic myelogenous leukem ...... ct of the bcr/abl hybrid gene.
@en
The chronic myelogenous leukem ...... ct of the bcr/abl hybrid gene.
@nl
P2093
P356
P1433
P1476
The chronic myelogenous leukem ...... ct of the bcr/abl hybrid gene.
@en
P2093
Baltimore D
Ben-Neriah Y
P304
P356
10.1126/SCIENCE.3460176
P407
P577
1986-07-01T00:00:00Z