Direct H atom abstraction from spore photoproduct C-6 initiates DNA repair in the reaction catalyzed by spore photoproduct lyase: evidence for a reversibly generated adenosyl radical intermediate.
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Crystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymesSpore photoproduct lyase: the known, the controversial, and the unknownStructural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzymeCrystal structures and repair studies reveal the identity and the base-pairing properties of the UV-induced spore photoproduct DNA lesionA Radical Transfer Pathway in Spore Photoproduct LyaseRadical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanismRescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyaseCharacterization of an active spore photoproduct lyase, a DNA repair enzyme in the radical S-adenosylmethionine superfamilyGlutamate 2,3-aminomutase: a new member of the radical SAM superfamily of enzymesComplete stereospecific repair of a synthetic dinucleotide spore photoproduct by spore photoproduct lyaseSpectroscopic, steady-state kinetic, and mechanistic characterization of the radical SAM enzyme QueE, which catalyzes a complex cyclization reaction in the biosynthesis of 7-deazapurinesRadical SAM enzymes in methylation and methylthiolationChemoselective deprotection of triethylsilyl ethers.Stoichiometry of the redox neutral deamination and oxidative dehydrogenation reactions catalyzed by the radical SAM enzyme DesII.Unusually large deuterium discrimination during spore photoproduct formation.Combined Mössbauer spectroscopic, multi-edge X-ray absorption spectroscopic, and density functional theoretical study of the radical SAM enzyme spore photoproduct lyase.Adenosyl radical: reagent and catalyst in enzyme reactions.The spore photoproduct lyase repairs the 5S- and not the 5R-configured spore photoproduct DNA lesion.Dinucleotide spore photoproduct, a minimal substrate of the DNA repair spore photoproduct lyase enzyme from Bacillus subtilis.Insight in DNA Repair of UV-induced Pyrimidine Dimers by Chromatographic Methods.Characterization of a new thermophilic spore photoproduct lyase from Geobacillus stearothermophilus (SplG) with defined lesion containing DNA substrates.An efficient deprotection of N-trimethylsilylethoxymethyl (SEM) groups from dinucleosides and dinucleotides.Probing the reaction mechanism of spore photoproduct lyase (SPL) via diastereoselectively labeled dinucleotide SP TpT substrates.Inter-strand photoproducts are produced in high yield within A-DNA exposed to UVC radiationChemical synthesis, crystal structure and enzymatic evaluation of a dinucleotide spore photoproduct analogue containing a formacetal linkerMechanistic studies of the radical SAM enzyme spore photoproduct lyase (SPL).Solution phase dynamics of the DNA repair enzyme spore photoproduct lyase as probed by H/D exchange.Radical SAM enzymes in the biosynthesis of sugar-containing natural products.Photochemistry and Photobiology of the Spore Photoproduct: A 50-Year Journey.Mechanistic studies of the spore photoproduct lyase via a single cysteine mutationStructural and functional comparison of HemN to other radical SAM enzymes.Covalent intermediate in the catalytic mechanism of the radical S-adenosyl-L-methionine methyl synthase RlmN trapped by mutagenesis.Structural diversity in the AdoMet radical enzyme superfamily.Spores of Bacillus subtilis: their resistance to and killing by radiation, heat and chemicals.Chemical syntheses of oligodeoxyribonucleotides containing spore photoproduct.Mechanistic Investigation of the Radical S-Adenosyl-L-methionine Enzyme DesII Using Fluorinated AnaloguesThe enzyme-mediated direct reversal of a dithymine photoproduct in germinating endosporesMultinuclear NMR and kinetic analysis of DNA interstrand cross-link formation.DNA repair and free radicals, new insights into the mechanism of spore photoproduct lyase revealed by single amino acid substitutionThe thiamine biosynthetic enzyme ThiC catalyzes multiple turnovers and is inhibited by S-adenosylmethionine (AdoMet) metabolites
P2860
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P2860
Direct H atom abstraction from spore photoproduct C-6 initiates DNA repair in the reaction catalyzed by spore photoproduct lyase: evidence for a reversibly generated adenosyl radical intermediate.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Direct H atom abstraction from ...... adenosyl radical intermediate.
@en
Direct H atom abstraction from ...... adenosyl radical intermediate.
@nl
type
label
Direct H atom abstraction from ...... adenosyl radical intermediate.
@en
Direct H atom abstraction from ...... adenosyl radical intermediate.
@nl
prefLabel
Direct H atom abstraction from ...... adenosyl radical intermediate.
@en
Direct H atom abstraction from ...... adenosyl radical intermediate.
@nl
P356
P1476
Direct H atom abstraction from ...... adenosyl radical intermediate.
@en
P2093
Jennifer Cheek
P304
P356
10.1021/JA017784G
P407
P577
2002-03-01T00:00:00Z